2010 Fiscal Year Final Research Report
Signal transduction molecules associated with the induction and maintenance of airway goblet cell hyperplasia
| Project/Area Number |
20590907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TAMAOKI Jun Tokyo Women's Medical University, 医学部, 教授 (60147395)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 気管支喘息 / 杯細胞過形成 / 細胞増殖 / ムチン遺伝子 / 上皮細胞成長因子 / 気道過敏性 / 気道リモデリング |
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| Research Abstract |
We studied human airway epithelial cells and found that stimulation with TGFα, a ligand of epidermal growth factor receptor (EGFR), increased the expression of genes and proteins of MUC5AC and Bcl-2, and that these effects were inhibited by EGFR and NFκB inhibitors. Furthermore, mucus hypersecretion and airway hyperresponsiveness in the rat model of asthma were attenuated by pretreatment with an EGFR inhibitor. These results suggest that EGFR may play an important role as a signal transduction molecule in airway goblet cell hyperplasia.
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Research Products
(58 results)
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[Book] Airway Secretion Research2009
Author(s)
Tamaoki J, Arai N, Tagaya E, Kondo M, Kawagoe M, Kimura N, Nagai A
Total Pages
17-24
Publisher
Japanese Association for Airway Secretion Research
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