2010 Fiscal Year Final Research Report
To overcome the intractable chronic cough : mechanism of cough and development of therapy
| Project/Area Number |
20590916
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
FUJIMURA Masaki Kanazawa University, 医学系, 准教授 (90190066)
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Nobuyuki 金沢大学, 附属病院, 助教 (30334767)
OGAWA Haruhiko 金沢大学, 医学系, 協力研究員 (70401908)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 慢性咳嗽 / 難治性 / 咳嗽発生機序 / 知覚神経 / 平滑筋収縮 |
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| Research Abstract |
It has been disclosed that there are at least two pathway of cough reflex : (1) increased cough receptor sensitivity (atopic cough) or hyper-stimulation to cough receptors (sinobronchial syndrome) which are present in inter- and sub epithelium of airway, (2) increased response of sensory nerve endings (Adelta-fibers) in intra- and peri-smooth muscle layer to the smooth muscle contraction (cough variant asthma) or hyper-stimulation (strong smooth muscle contraction) to the nerve endings.
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