2010 Fiscal Year Final Research Report
Identification of Epithelial-to-Mesenchymal Transition-Associated Genes as Therapeutic Targets for Lung Cancer
| Project/Area Number |
20590919
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | National Institute for Longevity Sciences,NCGG |
|---|
Principal Investigator |
SATO Mitsuo National Institute for Longevity Sciences,NCGG, 大学院・医学系研究科, 特任助教 (70467281)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Yoshinori 名古屋大学, 大学院・医学系研究科, 教授 (20270986)
ANDO Yichi 名古屋大学, 医学部附属病院, 准教授 (20270986)
SAWAKI Masataka 名古屋大学, 大学院・医学系研究科, 特任講師 (20402597)
MITSUMA Ayako 名古屋大学, 大学院・医学系研究科, 特任助教 (10467326)
KAWADA Kenji 名古屋大学, 医学部附属病院, 病院助手 (30418743)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 上皮間葉系細胞転換 / 非閉塞性肺疾患 |
|---|
| Research Abstract |
The aim of this study is to identify epithelial-to-mesenchymal transition (EMT)-associated genes as novel therapeutic targets for lung cancer. While several EMT-inducing genes have been discovered, which of these have the dominant role in EMT of lung cancer was not clear. We found that among four EMT-inducing genes (ZEB1, TWIST, SLUG, SIP1) ZEB1 plays the dominant role in EMT of lung cancer. Furthermore, we found that ZEB1 knockdown suppresses the growth of lung cancer cells. In addition, we also showed ZEB1 knockdown suppresses the growth of malignant pleural mesothelioma cells. These results suggest that ZEB1 may be a promising therapeutic target for lung cancer and malignant pleural mesothelioma.
|
