2010 Fiscal Year Final Research Report
the research related to the pathogenesis and novel treatment of pulmonary hypertension making use of genetically-modified mouse
| Project/Area Number |
20590920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Mie University |
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Principal Investigator |
MARUYAMA Junko Mie University, 医用工学部, 教授 (50263017)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Kazuo 三重大学, 大学院・医学系研究科, 教授 (20181828)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 炎症 / 右室肥大 / 肺胞洗浄 / モノクロタリン / CD4 / CD8 |
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| Research Abstract |
To study the role of CD4/CD8 T cell in the pathogenesis of pulmonary hypertension (PH), the severity of lung inflammation and right ventricular hypertrophy(RVH) was evaluated in monocrotaline(MCT)-induced CD4- or CD8- deficient mice as well as wild-type mice. The inflammation responses in lung were observed in all MCT-induced groups, however, RVH were only observed in wild -type mice, not CD4- nor CD8- deficient mice. From all these results, CD4 and CD8 T cell groups might be associated with the development of pulmonary hypertension.
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[Journal Article] Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit.2009
Author(s)
Nakamura A, Wada H, Ikejiri M, Hatada T, Sakurai H, Matsushima Y, Nishioka J, Maruyama K, Isaji S, Takeda T, Nobori T.
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Journal Title
Shock. 31(6)
Pages: 586-591
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