2010 Fiscal Year Final Research Report
Effects of obstructive sleep apnea with intermittent and sustained hypoxia on platelet aggregability and adipocyte.
| Project/Area Number |
20590921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
CHIN Kazuo Kyoto University, 大学院・医学研究科, 教授 (90197640)
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| Co-Investigator(Kenkyū-buntansha) |
OGA Toru 京都大学, 大学院・医学研究科, 講師 (90378670)
HORIUCHI Hisanori 東北大学, 加齢研究所, 教授 (90291426)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 閉塞型睡眠時無呼吸 / 血小板凝集能 / 持続的低酸素 / 間欠的低酸素 / 心血管障害 |
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| Research Abstract |
We showed that platelet aggregability was increased in patients with moderate-to-severe obstructive sleep apnea (OSA) partly through an intermittent hypoxia and reoxygenation phenomenon, which is pathophysiologically characteristic of OSA. As the effects of the severity of OSA on platelet aggregability were stronger in patients with vascular risk factors, the co-existence of OSA should be examined for the treatment of patients with multiple risk factors. Continuous therapy with continuous positive airway pressure (CPAP) improved platelet aggregability at 90 days. Thus, one of the reasons for the increase in cardiovascular events in OSA could be increased platelet aggregability. Under the hypoxic conditions which were induced by our machine, intermittent hypoxia induced TNF-α、and sustained hypoxia induced hypoxia inducible factor-1 (HIF-1) in HeLa cells.
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[Journal Article] Associations between obstmctive sleep apnea, metabolic syndrome and sleep duration, as measured with an actigraph, in an urban male working population in Japan.2010
Author(s)
Chin K, Oga T, Takahashi K, Takegami M, Nakayama-Ashida Y, Wakamura T, Sumi K, Nakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H.
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Journal Title
Peer Reviewed
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[Journal Article] Effects of obstructive sleep apnea with intermittent hypoxia on platelet aggregability.2009
Author(s)
Oga T, Chin K, Tabuchi A, Sumi K, Takahashi K,Handa T, Takahashi K, Taniguchi R, Kondo H, Kawato M'Morimoto T, Mishima M, Kita T, Horiuchi H
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Journal Title
Journal of Atheroclerosis and Thrombosis 16
Pages: 862-869
Peer Reviewed
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[Journal Article] Acylated ghrelin level in patients with obstructive sleep apnoea befbre and after nasal CPAP treatment.2008
Author(s)
Takahashi K, Chin K, Akamizu T, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Tsuboi T, Fukuhara S, Kangawa K, Mishima M.
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Journal Title
Respirology 13
Pages: 810-816
Peer Reviewed
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[Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.2008
Author(s)
Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M.
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Journal Title
Antioxtdemts & Redox signeding 10
Pages: 715-726
Peer Reviewed
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[Journal Article] Effects of the presence of hypertension on the relationship between obstructive sleep apnoea and sleepiness.
Author(s)
Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka, Y,Wakamura T, Fukuhara S, Mishima M, Kadotani H.
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Journal Title
Journal of Sleep Rrsecrch in press
Peer Reviewed
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