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2010 Fiscal Year Final Research Report

Molecular mechanisms coordinating between cell cycle and differentiation in lung epithelial cells

Research Project

  • PDF
Project/Area Number 20590928
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKumamoto University

Principal Investigator

FUJIMOTO Tetsuhiro  Kumamoto University, 大学院・生命科学研究部, 助教 (70359818)

Co-Investigator(Kenkyū-buntansha) ITO Takaaki  熊本大学, 大学院・生命科学研究部, 教授 (70168392)
Project Period (FY) 2008 – 2010
Keywords細胞周期 / 細胞癌化 / cyclin D1 / RUNX3 / p21
Research Abstract

Transcriptional function of cyclin D1, whose deregulation is frequently observed in human cancers, has been suggested to contribute to cancer formation. We show that cyclin D1 protein inhibits RUNX3 activity by directly binding to it andB interfering with its interaction with p300 interaction in lung cancer cells. Cyclin D1 inhibits p300-dependent RUNX3 acetylation and negatively regulates cyclin-dependent kinase (cdk) inhibitor p21 expression. These transcriptional effects of cyclin D1 do not require cdk4/6 kinase activation. We propose that cyclin D1 provides a transcriptional switch that allows the tumor suppressor activity of RUNX3 to be repressed in cancer cells.

  • Research Products

    (3 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Nucleostemin affects the proliferation but not differentiation of oral squamous cell carcinoma cells2011

    • Author(s)
      Yoshida R, Fujimoto T, Kudoh S, Nagata M, Nakayama H, Shinohara M, Ito T
    • Journal Title

      Cancer Science Vol.102、No.7

      Pages: 1418-1423

    • Peer Reviewed
  • [Journal Article] Cyclin D1 blocks the anti-proliferative funcution of RUNX3 by interfering with RUNX3-p300 interaction2010

    • Author(s)
      Iwatani K, Fujimoto T, Ito T
    • Journal Title

      Biochemical and Biophysical Research Communications Vol.400、No.3

      Pages: 426-431

    • Peer Reviewed
  • [Presentation] 細胞周期制御因子cyclin D1による転写制御因子RUNX3との相互作用を介した肺腺癌細胞の増殖制御機構2009

    • Author(s)
      藤本哲広
    • Organizer
      第98回日本病理学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-05-02

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Published: 2012-01-26   Modified: 2016-04-21  

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