2010 Fiscal Year Final Research Report
Functional analysis of Mycoplasma pneumoniae-derived lipoproteins in pneumonia onset
| Project/Area Number |
20590938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
KUWANO Koichi Kurume University, 医学部, 教授 (60215118)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takashi 久留米大学, 医学部, 助教 (40320155)
KIDA Yutaka 久留米大学, 医学部, 講師 (30309752)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 感染症 / 肺炎 / マイコプラズマ / 炎症 / リポプロテイン / TLR |
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| Research Abstract |
Mycoplasma pneumoniae is known to cause pneumonia in humans. It is, however, unclear how pneumonia occurs. Our laboratory previously reported that Mycoplasma pneumoniae-derived lipoproteins induce inflammatory responses. We then examined the interaction between the lipoproteins and host in order to elucidate the onset mechanisms. We found that the lipoproteins are extremely important in the onset of mycoplasma-pneumonia.
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