2010 Fiscal Year Final Research Report
Development of estimating system of hazard effect of nanomaterials
| Project/Area Number |
20590939
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
MORIMOTO Yasuo University of Occupational and Environmental Health, Japan, 産業生態科学研究所, 教授 (30258628)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MYOJO Toshihiko 産業医科大学, 産業生態科学研究所, 教授 (00209959)
HASHIBA Masayoshi 産業医科大学, 産業生態科学研究所, 専門修練医 (90566431)
TANAKA Isamu 産業医科大学, 産業生態科学研究所, 名誉教授 (00038035)
HIROHASHI Masami 産業医科大学, 産業生態科学研究所, 教務職員 (50389475)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | ナノ粒子 / 肺障害 / キャラクタリゼーション / ハザード / 環境 |
|---|
| Research Abstract |
We examined studies using characterized nano and fibrous materials in order to establish the estimating system of hazard effect of these materials. In intratracheal instillation studies, nickel oxide nanomaterials with agglomerates micron-size, high dose of titanium dioxide nanoparticles and potassium octatitanate Whiskers (PT-1) induced the pulmonary inflammation in rat lung. In vitro study using alveolar epithelial cell lines, nickel oxide induced IL-8 concentration and titanium dioxide did not. These studies are useful to estimate the harmful effect of nano and fibrous materials.
|
-
[Journal Article] Pulmonary Toxicity Following an Intratracheal Instillation of Nickel oxide Nanoparticle Agglomerates.2011
Author(s)
Morimoto Y, Hirohashi M, Ogami A, Oyabu T, Myojo T, Hashiba M, Mizuguchi Y, Kambara T, Lee BW, Kuroda E, Tanaka I
-
Journal Title
J Occup Health. (in press)
Peer Reviewed
-
[Journal Article] Expression of Heme Oxygenase-1 in the lungs of Rats Exposed to Potassium Octatianate whiskers.2011
Author(s)
Obata Y, Morimoto Y, Hirohashi M, Ogami A, Oyabu T, Myojo T, Kawanami S, Horie S, Nagatomo H, Murakami M, Tanaka I
-
Journal Title
J Occup Health. (in press)
Peer Reviewed
-
-
-
-
-
-
