2010 Fiscal Year Final Research Report
Analysis of urine acidification mechanism through calcium-sensing receptor
| Project/Area Number |
20590942
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | カルシウム感知受容体 / 腎髄質部太いヘンレの上行脚 / 微小単離尿細管灌流法 |
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| Research Abstract |
We examined whether Calcium-sensing receptor (CaR)activationcaused acid secretion in the medullary thick ascending limb of mouse kidney using i^nv^itro microperfusion. We verified that Neomycin (which activates CaR)induced intracellular alkalinization in HCO^-_3/C_O2-buffer. Besides, we succeeded to establish that this regulatory mechanism is luminal K^+-dependent but luminal Na^+ independent for the first time.
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