2010 Fiscal Year Final Research Report
A role of SHPS-1/CD47 signaling pathway in the glomerular barrier function
| Project/Area Number |
20590945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
NOJIMA Yoshihisa Gunma University, 大学院・医学系研究科, 教授 (90201699)
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| Project Period (FY) |
2008 – 2010
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| Keywords | SHPS-1 / SIRP-a / 糸球体バリアー機能 / チロシン脱リン酸化 |
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| Research Abstract |
SHPS-1 (SIRP-α) is a transmembrane protein having ITIM motif in its cytoplasmic domain. When the ITIM motif in SHPS-1 is tyrosine-phospholylated by a variety of stimuli, SHPS-1 binds tyrosine phosphatases, SHP-1 or SHP-2, which dephospholylates neighboring proteins and transmits signals to downstream. In this study, we have shown that SHPS-1 is expressed on podocytes and plays a significant role in structure and function of podocytes by using mutant mice expressing SHPS-1 with a deleted cytoplasmic domain. The results strongly suggest that the tyrosine-dephosphorylation system is involved in maintaining the barrier function of glomerulus.
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[Journal Article] Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy.2009
Author(s)
Sakurai N, Kuroiwa T, Ikeuchi H, Hiramatsu N, Takeuchi S, Tomioka M, Shigehara T, Maeshima A, Kaneko Y, Hiromura K, Kopp JB, Nojima Y.
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Journal Title
Nephrol Dial Transplant. 24(8)
Pages: 2378-83
Peer Reviewed
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