2010 Fiscal Year Final Research Report
Establishment of a novel therapy for proteinuria
Project/Area Number |
20590950
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Niigata University |
Principal Investigator |
KAWACHI Hiroshi Niigata University, 医歯学系, 教授 (60242400)
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Project Period (FY) |
2008 – 2010
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Keywords | 蛋白尿 / 糸球体上皮細胞 / スリット膜 / アンジオテンシン / ポドプラニン / シナプス小胞 |
Research Abstract |
The aim of this project was to identify the target molecules for establishment of a novel therapy for proteinuria. This study demonstrated that the stimulation to type II receptor of angiotensin II and the enhancement of the function of synaptic vesicle molecules have protective effects for slit diaphragm.
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[Journal Article] Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys.2011
Author(s)
Saito A, Miyauchi N, Hashimoto T, Karasawa T, Han GD, Kayaba M, Sumi T, Tomita M, Ikezumi Y, Suzuki K, Koitabashi Y, Shimizu F, Kawachi H.
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Journal Title
Am J Physiol Regul Integr Comp.Physiol 300
Pages: R340-348
Peer Reviewed
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[Journal Article] Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium.2011
Author(s)
Suzuki K, Sun X, Nagata M, Kawase T, Yamaguchi H, Sukumaran V, Kawauchi Y, Kawachi H, Nishino T, Watanabe K, Yoneyama H, Asakura H.
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Journal Title
Pathol Int. 61
Pages: 228-238
Peer Reviewed
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[Journal Article] A notable case report of May-Hegglin anomaly with immune complex-related nephropathy : a genetic and histological analysis.2011
Author(s)
Ohtsuka Y, Kanaji T, Nishi M, Sakai N, Sato T, Aoki S, Wakayama K, Nakazato S, Hisano S, Sado Y, Kawachi H, Izuhara K, Hamasaki Y.
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Journal Title
Clin Nephrol. 75
Pages: 255-262
Peer Reviewed
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[Journal Article] Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy : potential role in mesangial matrix expansion.2011
Author(s)
Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Yamada T, Imai N, Narita I, Kawachi H, Polkinghorne KR, Nikolic-Paterson DJ, Uchiyama M.
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Journal Title
Histopathology. 58
Pages: 198-210
Peer Reviewed
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[Journal Article] CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats.2011
Author(s)
Miyasato K, Takabatake Y, Kaimori J, Kimura T, Kitamura H, Kawachi H, Li XK, Hunig T, Takahara S, Rakugi H, Isaka Y.
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Journal Title
Clin Exp Nephrol. 15
Pages: 50-57
Peer Reviewed
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[Journal Article] Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.2010
Author(s)
Tanaka M, Asada M, Higashi AY, Nakamura J, Oguchi A, Tomita M, Yamada S, Asada N, Takase M, Okuda T, Kawachi H, Economides AN, Robertson E, Takahashi S, Sakurai T, Goldschmeding R, Muso E, Fukatsu A, Kita T, Yanagita M.
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Journal Title
J Clin Invest.Mar 120
Pages: 768-777
Peer Reviewed
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[Journal Article] ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis.2010
Author(s)
Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, Kitamura A, Matsuura S, Yoshizumi M, Tamaki T, Kawachi H, Kagami S.
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Journal Title
Am J Physiol Renal Physiol. 298
Pages: F167-176
Peer Reviewed
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[Journal Article] Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1.2010
Author(s)
Sun X, Suzuki K, Nagata M, Kawauchi Y, Yano M, Ohkoshi S, Matsuda Y, Kawachi H, Watanabe K, Asakura H, Aoyagi Y.
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Journal Title
Pathol Int. 60
Pages: 93-101
Peer Reviewed
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[Journal Article] Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats.2009
Author(s)
Okada T, Sakaguchi T, Hatamura I, Saji F, Negi S, Otani H, Muragaki Y, Kawachi H., Shigematsu T.
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Journal Title
Clin Exp Nephrol 13
Pages: 438-446
Peer Reviewed
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[Journal Article] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats.2009
Author(s)
Matsui I, Hamano T, Tomida K, Inoue K, Takabatake Y, Nagasawa Y, Kawada N, Ito T, Kawachi H, Rakugi H, Imai E, Isaka Y.
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Journal Title
Nephrol Dial Transplant 24
Pages: 2354-2361
Peer Reviewed
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[Journal Article] IFN-inducible protein 10 (CXCL10) regulates tubular cell proliferation in renal ischemia-reperfusion injury.2008
Author(s)
Furuichi K, Wada T, Kitajikma S, Toyama T, Okumura T, Hara A, Kawachi H, Shimizu F, Sugaya T, Mukaida N, Narumi S, Matsushima K, Kaneko S.
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Journal Title
Nephron Exp Nephrol. 109
Pages: c29-38
Peer Reviewed
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[Journal Article] Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative.2008
Author(s)
Kramer S, Kron S, Wang-Rosenke Y, Loof T, Khadzhynov D, Morgera S, Kawachi H, Shimizu F, Martini S, Neumayer HH, Peters H.
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Journal Title
Am J Physiol Renal Physiol. 294
Pages: F801-811
Peer Reviewed
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[Journal Article] Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat.2008
Author(s)
Kramer S, Wang-Rosenke Y, Scholl V, Binder E, Loof T, Khadzhynov D, Kawachi H, Shimizu F, Diekmann F, Budde K, Neumayer HH, Peters H.
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Journal Title
Am J Physiol Renal Physiol. 294
Pages: F440-449
Peer Reviewed
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[Remarks] 河内裕:糸球体上皮細胞の新しい機能分子-蛋白尿の新規治療法開発のためのターゲット分子の探索-第31回腎臓セミナー、2009、東京
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[Remarks] 河内裕:ポドサイト研究の最前線-臨床応用に向けての展望-第1回Front J、2009、東京
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[Remarks] 河内裕:スリット膜関連分子-最近の知見-第93回東京腎生理集談会、2008、東京
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