2010 Fiscal Year Final Research Report
Proteomic analysis of transgenic rat specifically expressing ADAMTS-8 in podocyte
| Project/Area Number |
20590951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
GOTO Shin Niigata University, 医歯学系, 助教 (00463969)
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817)
YAMAMOTO Tadashi 新潟大学, 医歯学系, 教授 (30092737)
IGUCHI Seitaro 新潟大学, 大学院・医歯学総合研究科, 特任教授 (20420309)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ADAMTS-8 / transgenic rat / proteome / nephrotic syndrome / phage display |
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| Research Abstract |
Nephrotic syndrome present massive proteinuria, however, underling mechanisms remain elusive. We focused an interaction between the cell-cell contact which is involved with urine production, and proteinase produced in these cells (ADAMTS-8). Rat with forced expression of ADAMTS-8 gradually showed proteinuria. Using these rat model, we revealed molecules associated with development of proteinuria.
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Research Products
(11 results)
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[Journal Article] Novel expression of claudin-5 in glomerular podocytes.2011
Author(s)
Koda R, Zhao L, Yaoita E, Yoshida Y, Tsukita S, Tamura A, Nameta M, Zhang Y, Fujinaka H, Magdeldin S, Xu B, Narita I, Yamamoto T.
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Journal Title
Cell Tissue Res. 343
Pages: 637-648
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[Journal Article] Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis.2010
Author(s)
Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, Yamamoto M, Takahashi H, Matsui S, Nakada S, Origuchi T, Hirabayashi A, Homma N, Tsubata Y, Takata T, Wada Y, Saito A, Fukase S, Ishioka K, Miyazaki K, Masaki Y, Umehara H, Sugai S, Narita I.
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Journal Title
Kidney Int 78
Pages: 1016-1023
Peer Reviewed
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