Possible involvement of CD45^+/collagen I^+ dual positive cells in renal fibrosis and cardiorenal syndrome.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590952
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: WADA Takashi Kanazawa University, 医学系, 教授 (40334784)
• Project Period (FY): 2008 – 2010
• Keywords: 炎症 / 免疫担当細胞 / CD45 / 心臓病 / 腎臓病 / 線維化 / コラーゲン / 臨床検査診断

Research Abstract

CD45^<+/>Collagen I^+ dual positive cells migrate into fibrotic kidney dependent on chemokine system, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating renal fibrosis. In addition, our present data suggest the possible involvement of CD45^+/Collagen I^+ dual positive cells in cardiac fibrosis, closely related to renal lesions. Furthermore, the detection of CD45^+/Collagen I^+ dual positive cells in circulation has been established in this study.

Research Products

• [Journal Article] Involvement of bone-marrow-derived cells in kidney fibrosis. (2011)
  • Author(s): Wada T, Sakai N, Sakai Y, Matsushima K, Kaneko S, Furuichi K.
  • Journal Title: Clin Exp Nephrol. 15 Pages: 8-13
  • Peer Reviewed
• [Journal Article] Fibrocytes are involved in the pathogenesis of human chronic kidney disease. (2010)
  • Author(s): Sakai N, Furuichi K, Shinozaki Y, Yamauchi H, Toyama T, Kitajima S, Okumura T, Kokubo S, Kobayashi M, Takasawa K, Takeda SI, Yoshimura M, Kaneko S, Wada T.
  • Journal Title: Hum Pathol. 41 Pages: 672-678
  • Peer Reviewed
• [Journal Article] Involvement of CD11b(+) GR-1 (low) cells in autoimmune disorder in MRL-Fas^<lpr> mouse. (2010)
  • Author(s): Iwata Y, Furuichi K, Kitagawa K, Hara A, Okumura T, Kokubo S, Shimizu K, Sakai N, Sagara A, Kurokawa Y, Ueha S, Matsushima K, Kaneko S, Wada T.
  • Journal Title: Clin Exp Nephrol. 14 Pages: 411-417
  • Peer Reviewed
• [Journal Article] Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease. (2009)
  • Author(s): Furuichi K, Kaneko S, Wada T.
  • Journal Title: Clin Exp Nephrol. 13 Pages: 9-14
  • Peer Reviewed
• [Journal Article] Dendritic cells contribute to autoimmune kidney injury in MRL-Fas^<lpr> mice (2009)
  • Author(s): Iwata Y, Furuichi K, Sakai N, Yamauchi H, Shinozaki Y, Zhou H, Kurokawa Y, Toyama T, Kitajima S, Okumura T, Yamada S, Maruyama I, Matsushima K, Kaneko S, Wada T.
  • Journal Title: J Rheumatol. 36 Pages: 306-314
  • Peer Reviewed
• [Journal Article] The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. (2008)
  • Author(s): Sakai N, Wada T, Iwai M, Horiuchi M, Matsushima K, Kaneko S.
  • Journal Title: J Hypertens. 26 Pages: 780-790
  • Peer Reviewed
• [Journal Article] IFN-inducible Protein 10 (CXCL10) Regulates Tubular Cell Proliferation in Renal Ischemia-Reperfusion Injury. (2008)
  • Author(s): Furuichi K, Wada T, Kitajikma S, Toyama T, Okumura T, Hara A, Kawachi H, Shimizu F, Sugaya T, Mukaida N, Narumi S, Matsushima K, Kaneko S.
  • Journal Title: Nephron Exp Nephrol. 109 Pages: 29-38
  • Peer Reviewed
• [Journal Article] The role of chemokines in glomerulonephritis. (2008)
  • Author(s): Wada T, Matsushima K, Kaneko S
  • Journal Title: Frontiers in Bioscience 13 Pages: 3966-3974
  • Peer Reviewed
• [Journal Article] Roles of chemokines in renal ischemia reperfusion injury. (2008)
  • Author(s): Furuichi K, Wada T, Kaneko S, Murphy PM.
  • Journal Title: Frontiers in Bioscience 13 Pages: 4021-4028
  • Peer Reviewed
• [Journal Article] Fibrocyte : New participant in the pathogenesis of renal fibrosis. (2008)
  • Author(s): Sakai N, Wada T, Matsushima K, Kaneko S.
  • Journal Title: Inflammation and regeneration 28 Pages: 20-26
• [Presentation] 腎線維化にはたす骨髄由来細胞の意義 (2010)
  • Author(s): 和田隆志
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2010-12-18
• [Presentation] 慢性腎臓病と炎症・免疫担当細胞 (2010)
  • Author(s): 和田隆志
  • Organizer: 第71回日本小児科学会沖縄地方会
  • Place of Presentation: 沖縄県医師会館(沖縄県)
  • Year and Date: 2010-09-12
• [Presentation] 腎間質線維化と骨髄由来細胞 (2010)
  • Author(s): 和田隆志
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2010-06-17
• [Presentation] 炎症と腎線維化 (2009)
  • Author(s): 和田隆志
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] 腎臓病における臨床検査の展望 (2009)
  • Author(s): 和田隆志
  • Organizer: 第20回日本臨床化学会東海北陸支部総
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-08-08
• [Presentation] Fibrocyte and Renal Injury (2008)
  • Author(s): 和田隆志
  • Organizer: 41st Annual Meeting of American Society of Nephrology
  • Place of Presentation: フィラデルフィア(米国)
  • Year and Date: 2008-11-06
• [Presentation] 腎間質線維化:骨髄由来細胞の関与とその制御 (2008)
  • Author(s): 和田隆志
  • Organizer: 第38回日本腎臓学会東部学術大会
  • Place of Presentation: 六本木アカデミーヒルズ40(東京都)
  • Year and Date: 2008-10-12
• [Presentation] 骨髄由来細胞からみた腎臓線維化機構 (2008)
  • Author(s): 和田隆志
  • Organizer: 第49回日本組織細胞化学会総会学術集会
  • Place of Presentation: 長崎大学(長崎県)
  • Year and Date: 2008-10-05
• [Book] Fibrocytes in renal Fibrosis, World Scientific Press
  • Author(s): Sakai N, Furuichi K, Matsushima K, Kaneko S, Wada T.
  • Publisher: in press
• [Patent(Industrial Property Rights)] 腎症の進行度の判定方法並びに線維化抑制剤 (2010)
  • Inventor(s): 和田隆志, 金子周一, 坂井宣彦
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 特許,特願:2010-281080
  • Filing Date: 2010-12-16