2010 Fiscal Year Final Research Report
Elucidate the role of BMP and BMP antagonist USAG-1 in the progression of chronic kidney diseases and therapeutic application
| Project/Area Number |
20590954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
YANAGITA Motoko Kyoto University, 次世代研究者育成センター, 准教授 (70378769)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Takeshi 金沢大学, 医学研究科, 教授 (60251055)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 慢性腎臓病 / 糸球体 / 尿細管 / 修復 |
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| Research Abstract |
Dialysis dependency is one of the leading causes of morbidity and mortality in the world, and once end-stage renal disease develops, it cannot be reversed by currently available therapy. Although the administration of large dose of bone morphogenetic protein7 (BMP7) has been shown to repair established renal injuries and improves renal function, pathophysiological role of endogenous BMP7 and regulatory mechanism of its activities remain elusive. Here we show that uterine sensitization-associated gene-1 (USAG-1), novel BMP antagonist abundantly expressed in the kidney, is the central negative regulator of BMP function in the kidney, and that inhibition of USAG-1 will be promising therapeutic trial for kidney diseases.
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[Journal Article] Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome2010
Author(s)
Mari Tanaka, Misako Asada, Atsuko Y Higashi, Jin Nakamura, Akiko Oguchi, Mayumi Tomita, Sachiko Yamada, Nariaki Asada, Masayuki Takase, Tomohiko Okuda, Hiroshi Kawachi, Aris N. Economides, Elizabeth Robertson, Satoru Takahashi, Takeshi Sakurai, Roel Goldschmeding, Eri Muso, Atsushi Fukatsu, Toru Kita, Motoko Yanagita
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Journal Title
J Clin Invest 120(3)
Pages: 768-77
Peer Reviewed
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[Journal Article] Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreER^<T2>2009
Author(s)
Atsuko Yoshioka Higashi, Tomokatsu Ikawa, Masamichi Muramatsu, Aris N.Economides, Akira Niwa, Tomohiko Okuda, Andrew J.Murphy, Jose Rojas, Toshio Heike, Tatsutoshi Nakahata, Hiroshi Kawamoto, Toru Kita, Motoko Yanagita
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Journal Title
J Immunol. 182(9)
Pages: 5633-40
Peer Reviewed
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[Journal Article] Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury2008
Author(s)
Mari Tanaka, Shuichiro Endo, Tomohiko Okuda, Aris N.Economides, David M.Valenzuela, Andrew J.Murphy, Elizabeth Robertson, Takeshi Sakurai, Atsushi Fukatsu, George D. Yancopoulos, Toru Kita, Motoko Yanagita
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Journal Title
Kidney Int. 73(2)
Pages: 181-91
Peer Reviewed
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[Presentation] BMP7 maintains nephron progenitor population and determines nephron number(Poster)2010
Author(s)
Mayumi Tomita, Itsuro Kazama, Nariaki Asada, Atsuko Y. Higashi, Shuichiro Endo, Toru Kita, Atsushi Fukatsu, Aris N. Economides, Elizabeth Robertson, Jordan A. Kreidberg, Motoko Yanagita
Organizer
American Society of Nephrology
Place of Presentation
Denver, CO, USA
Year and Date
2010-11-16
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[Presentation] BMP7 maintains nephron progenitor cells in kidney development2009
Author(s)
Mayumi Tomita, Itsuro Kazama, Nariaki Asada, Atsuko Y. Higashi, Shuichiro Endo, Toru Kita, Atsushi Fukatsu, Aris N.Economides, Elizabeth Robertson, Jordan A.Kreidberg, Motoko Yanagita
Organizer
American Society of Nephrology
Place of Presentation
USA
Year and Date
2009-11-02
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[Presentation] USAG-1 (uterine sensitization-associated gene-1), a novel BMP antagonist expressed in the kidney, exacerbates Alport glomeular pathogenesis2008
Author(s)
Mari Tanaka, Mayumi Tomita, Atsuko Higashi, Tomohiko Okuda, Atsushi Fukatsu, Toru Kita, Motoko Yanagita
Organizer
American Society of Nephrology Meeting
Place of Presentation
Philadelphia, PA, USA
Year and Date
2008-11-07
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[Remarks] 【テレビ、ラジオ】2010年2月9日テレビNHK総合「腎臓病起こすタンパク質特定京大チーム」同様の内容がNHKラジオでも報道されました。
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[Remarks] 【新聞】2010年2月9日朝日新聞「慢性腎臓病の治療法に光 京大チーム血液濾過障害仕組み解明」日本経済新聞「腎不全症状軽減に有望手法 京大が考案たんぱく質 働き抑制」毎日新聞「悪玉たんぱくで腎不全 京大 マウスで確認遺伝病進行の鍵」産経新聞「腎修復阻害、仕組み解明 京大、腎不全治療に期待」京都新聞「腎不全悪化の物質発見 京大グループ治療法の開発へ可能性」2010年2月15日読売新聞「腎臓病治療に光 アルポート症候群メカニズム解明」など【インターネットニュースサイト】2010年2月9日YAHOOニュース「腎不全悪化のタンパク質を発見 京大グループ 米医学誌に発表」アサヒ・ドット・コム「腎臓病の進行を抑える治療の可能性 京大グループ発見」
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