2010 Fiscal Year Final Research Report
Molecular mechanism of epithelialization by non-peptide, endogenous siderophores
| Project/Area Number |
20590955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
MORI Kiyoshi Kyoto University, 大学院・医学研究科, 特定准教授 (60343232)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腎臓学 / 生体分子 / 鉄 / 有機化学 / 腎不全 / リポカリン / バイオマーカー |
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| Research Abstract |
Neutrophil gelatinase-associated lipocalin (Ngal or LCN2) has a renoprotective activity, which is enhanced by the presence of enterochelin, an E. coli-derived siderophore [Mori et al. J Clin Invest 2005]. Purification of mammalian siderophores lead to identification of catechol and its derivatives [Bao et al. Nat Chem Biol 2010]. Catechol largely affects tissue distribution of iron in mammals. Ngal plays a renoprotective role in renal ischemia-reperusion injury, whereas enhances renal hypertrophy and kidney injury in 3/4 subtotal nephrectomy [Viau et al. J Clin Invest 2005]. Urinary Ngal levels are determined by renal synthesis, release from neutrophils, and impaired reabsorption at proximal tubules [Kuwabara et al. Kidney Int 2009]. Urinary Ngal is useful for the evaluation of disease severity and treatment efficacy of chronic kidney disease [Kasahara et al. Nephrol Dial Trasplant 2009]. Ngal reporter mice allow real-time visualization of spaciotemporal regulation of Ngal expression, and its changes by treating reagents [Paragas et al. Nat Med 2011].
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Research Products
(45 results)
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[Journal Article] The Ngal reporter mouse detects the response of the kidney to injury in real time.2011
Author(s)
N Paragas, A Qiu, Q Zhang, B Samstein, SX Deng, KM Schmidt-Ott, M Viltard, W Yu, CS Forster, G Gong, Y Liu, R Kulkarni, K Mori, A Kalandadze, AJ Ratner, P Devarajan, DW Landry, V D'Agati, CS Lin, J Barasch.
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Journal Title
Nat Med 17
Pages: 216-222
Peer Reviewed
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[Journal Article] Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.2010
Author(s)
A Viau, K El Karoui, D Laouari, M Burtin, C Nguyen, K Mori, E Pillebout, T Berger, TW Mak, B Knebelmann, G Friedlander, J Barasch, F Terzi.
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Journal Title
J Clin Invest 120
Pages: 4065-4076
Peer Reviewed
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[Journal Article] Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.2010
Author(s)
G Bao, M Clifton, TM Hoette, K Mori, SX Deng, A Qiu, M Viltard, D Williams, N Paragas, T Leete, R Kulkarni, X Li, B Lee, A Kalandadze, AJ Ratner, JC Pizarro, KM Schmidt-Ott, DW Landry, KN Raymond, RK Strong, J Barasch.
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Journal Title
Nat Chem Biol 6
Pages: 602-609
Peer Reviewed
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[Journal Article] Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.2010
Author(s)
H Yokoi, M Kasahara, M Mukoyama, K Mori, K Kuwahara, J Fujikura, Y Arai, Y Saito, Y Ogawa, T Kuwabara, A Sugawara, K Nakao
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Journal Title
Nephrol Dial Transplant 25
Pages: 2120-2124
Peer Reviewed
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[Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal and distal nephrons.2009
Author(s)
T Kuwabara, K Mori, M Mukoyama, M Kasahara, H Yokoi, Y Saito, T Yoshioka, Y Ogawa, H Imamaki, T Kusakabe, K Ebihara, M Omata, N Satoh, A Sugawara, J Barasch, K Nakao
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Journal Title
Kidney Int 75
Pages: 285-294
Peer Reviewed
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[Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.2008
Author(s)
T Nagae, K Mori, M Mukoyama, M Kasahara, H Yokoi, T Suganami, K Sawai, T Yoshioka, M Koshikawa, Y Saito, Y Ogawa, T Kuwabara, I Tanaka, A Sugawara, T Kuwahara, K Nakao
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Journal Title
Kidney Int 74
Pages: 70-80
Peer Reviewed
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[Journal Article] Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury.2008
Author(s)
TL Nickolas, MJ O'Rourke, J Yang, ME Sise, PA Canetta, N Barasch, C Buchen, F Khan, K Mori, J Giglio, P Devarajan, J Barasch.
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Journal Title
Ann Intern Med 148
Pages: 810-819
Peer Reviewed
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[Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.2008
Author(s)
H Yokoi, M Mukoyama, K Mori, M Kasahara, T Suganami, K Sawai, T Yoshioka, Y Saito, Y Ogawa, T Kuwabara, A Sugawara, K Nakao
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Journal Title
Kidney Int 73
Pages: 446-455
Peer Reviewed
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