2010 Fiscal Year Final Research Report
Gene expression profile of tonsils of patients with IgA nephropathy
| Project/Area Number |
20590957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
IMAI Enyu Osaka University, 大学院・医学系研究科, 特任准教授 (00223305)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Yasuyuki 大阪大学, 大学院・医学系研究科, 助教 (10379167)
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| Project Period (FY) |
2008 – 2010
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| Keywords | IgA腎症 / マイクロアレイ / APOBEC2 / 遺伝子解析 / 腎臓内科学 |
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| Research Abstract |
We analyzed the gene expression in the tonsils of patients with IgA nephropathy (N=23) using microarray, compared with those with patients suffering from chronic tonsillitis without IgAN (N=22). We confirmed12 up-regulated genes including APOBEC2, CALB2, DUSP27, and CXCL11. APOBEC2 was positively stained in the epithelium and the peripheral region of the germinal center. The APOBEC2 was confirmed to be elevated in the tonsils in another 73 IgAN patients. These results suggest that the APOBEC2 might be associated with development of IgAN.
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Research Products
(29 results)
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[Journal Article] Impact of age and overt proteinuria on outcomes of stage 3 to 5 chronic kidney disease in a referred cohort.2010
Author(s)
Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamura H, Imai E, Rakugi H, Isaka Y, Hayashi T
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Journal Title
Clin J Am Soc Nephrol. 5(9)
Pages: 1558-1565
Peer Reviewed
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[Journal Article] Cigarette smoking and progression of IgA nephropathy.2010
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Inoue K, Uehata T, Kaneko T, Okada N, Moriyama T, Horio M, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y
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Journal Title
Am J Kidney Dis 56(2)
Pages: 313-324
Peer Reviewed
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[Journal Article] Specialist care and improved long-term survival of dialysis patients.2010
Author(s)
Furumatsu Y, Nagasawa Y, Yamamoto R, Iio K, Iwatani H, Matsui I, Takabatake Y, Kawada N, Shoji T, Imai E, Isaka Y, Rakugi H
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Journal Title
Nephrol Dial Transplant. 25(6)
Pages: 1930-1935
Peer Reviewed
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[Journal Article] A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).2009
Author(s)
Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Uehata T, Kaneko T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H.
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Journal Title
Nephrol Dial Transplant. 24(12)
Pages: 3686-3694
Peer Reviewed
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[Journal Article] Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure.2009
Author(s)
Matsui I, Hamano T, Mikami S, Fujii N, Takabatake Y, Nagasawa Y, Kawada N, Ito T, Rakugi H, Imai E, Isaka Y.
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Journal Title
Kidney Int.
Pages: 915-928
Peer Reviewed
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[Journal Article] Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PTH and bone mineral density in non-diabetic predialysis CKD patients.2009
Author(s)
Tomida K, Hamano T, Mikami S, Fujii N, Okada N, Matsui I, Nagasawa Y, Moriyama T, Ito T, Imai E, Isaka Y, Rakugi H.
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Journal Title
Bone 44(4)
Pages: 678-683
Peer Reviewed
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[Journal Article] Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker.2008
Author(s)
Furumatsu Y, Nagasawa Y, Tomida K, Mikami S, Kaneko T, Okada N, Tsubakihara Y, Imai E, Shoji T.
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Journal Title
Hypertens Res. 31(1)
Pages: 59-67
Peer Reviewed
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