2010 Fiscal Year Final Research Report
Gene expression profile of tonsils of patients with IgA nephropathy
| Project/Area Number |
20590957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
IMAI Enyu Osaka University, 大学院・医学系研究科, 特任准教授 (00223305)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Yasuyuki 大阪大学, 大学院・医学系研究科, 助教 (10379167)
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| Project Period (FY) |
2008 – 2010
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| Keywords | IgA腎症 / マイクロアレイ / APOBEC2 / 遺伝子解析 / 腎臓内科学 |
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| Research Abstract |
We analyzed the gene expression in the tonsils of patients with IgA nephropathy (N=23) using microarray, compared with those with patients suffering from chronic tonsillitis without IgAN (N=22). We confirmed12 up-regulated genes including APOBEC2, CALB2, DUSP27, and CXCL11. APOBEC2 was positively stained in the epithelium and the peripheral region of the germinal center. The APOBEC2 was confirmed to be elevated in the tonsils in another 73 IgAN patients. These results suggest that the APOBEC2 might be associated with development of IgAN.
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Author(s)
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