2010 Fiscal Year Final Research Report
Analysis on the functional role of Vasohibin in CKD and therapeutic application
| Project/Area Number |
20590958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
MAESHIMA Youhei Okayama University, 病院, 講師 (10343287)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Yasufumi 東北大学, 加齢医学研究所腫瘍循環分野, 教授 (50178779)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 慢性腎臓病 / 血管新生 / 糖尿病性腎症 / Vasohibin-1 / アデノウィルス |
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| Research Abstract |
The population of CKD patients in Japan is estimated as 13.3 million people. CKD is a risk factor of end-stage renal disease as well as cardiovascular disorders. In the present study, we examined the functional role of Vasohibin-1, a negative feedback regulator of angiogenesis, in CKD and its potential therapeutic effects. Adenoviral transfer of Vasohibin-1 resulted in the amelioration of renal alterations in experimental models of mouse type 1 and 2 diabetic nephropathy. Vasohibin-1 exhibited anti-angiogenic effects as well as direct therapeutic effects on mesangial cells and podocytes. These results suggest the potential therapeutic efficacy of Vasohibin-1 in CKD.
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