Potential roles of dendritic cells in murine IgA nephropathy

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590963
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Juntendo University
• Principal Investigator: SUZUKI Yusuke Juntendo University, 医学部, 准教授 (70372935)
• Co-Investigator(Kenkyū-buntansha): TOMINO Yaqsuhiko 順天堂大学, 医学部, 教授 (60130077) ; HORIKOSHI Satoshi 順天堂大学, 医学部, 先任准教授 (80260884) ; KIHARA Masao 順天堂大学, 医学部, 助教 (50512604) ; SUZUKI Hitoshi 順天堂大学, 医学部, 助教 (10468572) ; NAKATA Junichiro 順天堂大学, 医学部, 助教 (20365638) ; YAMAJI Kenji 順天堂大学, 医学部, 助手 (90420835)
• Project Period (FY): 2008 – 2010
• Keywords: IgA腎症 / 樹状細胞 / 粘膜免疫 / ddYマウス / TLR9 / CD11c

Research Abstract

The present study demonstrated that mucosal activation of TLR9 on B cells and DC had different contributions to the progression of murine IgAN, presumably via formation of nephritogenic IgA and IgA-IgG IC, respectively.

Research Products

• [Journal Article] IgA腎症の病態における扁桃B細胞の役割 (2011)
  • Author(s): 鈴木祐介
  • Journal Title: 医学のあゆみ 236 Pages: 1193-1194
• [Journal Article] IgA腎症とHenoch-Schonlein紫斑病 (2011)
  • Author(s): 鈴木祐介
  • Journal Title: 腎と透析 70 Pages: 73-76
• [Journal Article] Clinicoepidemiological manifestations of RPGN and ANCA-associated vasculitides : an 11-year retrospective hospital-based study in Japan. (2010)
  • Author(s): 鈴木祐介, et al.
  • Journal Title: Mod Rheumatol. 20 Pages: 54-62
  • Peer Reviewed
• [Journal Article] Down-regulation of core 1{beta}1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1. (2010)
  • Author(s): Koshi Yamada, Yusuke Suzuki, et al.
  • Journal Title: Nephrol Dial Transplant. 25 Pages: 3890-3897
  • Peer Reviewed
• [Journal Article] Protective effects of tubular liver-type fatty acid binding protein in murine IgA nephropathy.
  • Author(s): Nan Zuo, Yusuke Suzuki, et al.
  • Journal Title: Nephrol Dial Transplant. (in Press)
  • Peer Reviewed
• [Journal Article] Reevaluation of Mucosa-Bone Marrow-Axis in IgA nephropathy with animal models.
  • Author(s): 鈴木祐介, et al.
  • Journal Title: ADVANCES IN OTO-RHINO-LARYNGOLOG. (in Press)
  • Peer Reviewed
• [Journal Article] Aberrant Glycosylation of IgA1 and Anti-Glycan Antibodies in IgA Nephropathy : Role of Mucosal Immune System.
  • Author(s): Jan Novak, Yusuke Suzuki, et al.
  • Journal Title: ADVANCES IN OTO-RHINO-LARYNGOLOG. (in Press)
  • Peer Reviewed
• [Presentation] Different Disease phenotypes differ by activation of TLR9 on dendritic cells (DC) and B cells in murine IgA nephropathy. (2010)
  • Author(s): 梶山忠弘, 鈴木祐介, et al.
  • Organizer: American Society of Nephrology Annual meeting 2010
  • Place of Presentation: Denver, USA
  • Year and Date: 2010-11-20
• [Presentation] Mucosa-Bone Marrow-Axis in IgA Nephropathy-Insights from Animal Models- (2010)
  • Author(s): 鈴木祐介, et al.
  • Organizer: The 7^<th> International Symposium on Tonsil and Mucosal Barriers of the Upper Airways
  • Place of Presentation: Asahikawa, Japan
  • Year and Date: 2010-07-09
• [Presentation] Different disease phenotypes by activation of TLR9 on dendritic cells(DC) and B cells in murine IgA nephropathy. (2010)
  • Author(s): 梶山忠弘, 鈴木祐介, et al.
  • Organizer: The 7^<th> International Symposium on Tonsil and Mucosal Barriers of the Upper Airways
  • Place of Presentation: Asahikawa, Japan
  • Year and Date: 2010-07-08
• [Presentation] IgA腎症モデルマウスにおける、感作抗原の相違がもたらす病態の多様性の検討 (2010)
  • Author(s): 梶山忠弘、鈴木祐介, 他
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17