2011 Fiscal Year Final Research Report
Understanding of cross-talk between glomerular cells in health and disease.
| Project/Area Number |
20590964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Tatsuo 順天堂大学, 医学部, 教授 (90114488)
ICHIMURA Koichiro 順天堂大学, 医学部, 准教授 (10343485)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 足細胞 / スリット膜 / シグナル伝達 |
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| Research Abstract |
Renal glomerulus is consisted with endothelial cells, podocytes and mesangial cells. These cells cooperate with each other for glomerular filtration ; however, the intercellular signaling molecules between glomerular cells are not fully determined. We demonstrate that SIRP-α, which recruits a broadly distributed tyrosine dephosphorylase SHP-2 to the plasma membrane, is located in podocytes. CD47, a ligand for SIRP-α, is located along the plasma membrane of mesangial cells, but not on podocytes. CD47 binds to the extracellular domain of SIRP-αa when mesangial cellsa are injured. The data suggest that the CD47-SIRP-α interaction may be functionally important in cell-cell communication in the diseased glomerulus.
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Research Products
(52 results)
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[Journal Article] Significance of broad distribution of electron-dense deposits in patients with IgA nephropathy2012
Author(s)
Kusaba G, Ohsawa I, Ishii M, Inoshita H, Takagi M, Tanifuji C, Takahashi K, Nakamoto J, Yoshida M, Ohi H, Horikoshi S, Kurihara H, Tomino Y
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Journal Title
Med Mol Morphol
Volume: 45(1)
Pages: 29-34
Peer Reviewed
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[Journal Article] The CXCL12(SDF-1)/CXCR4 axis is essential for the development of rRenal vasculature2009
Author(s)
Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, IsakaY
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Journal Title
J Am Soc Nephrol
Volume: 20
Pages: 1714-1723
Peer Reviewed
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[Journal Article] Critical role of ganglioside GM1 clustering in Laminin-1 induced neurite outgrowth signaling in PC12 cell and DRG neuron2009
Author(s)
Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi T, Sasaki T, Hattori N, Mizuno Y, Hozumi K, Yamada Y, Arikawa-Hirasawa E
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Journal Title
J Cell Sci
Volume: 122
Pages: 289-299
Peer Reviewed
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[Journal Article] An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms2009
Author(s)
Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S
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Journal Title
PLoS ONE
Volume: 4(1)
Pages: e4194
Peer Reviewed
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[Journal Article] Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils2008
Author(s)
Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa1 H, Nagaoka I
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Journal Title
Glycoconj J
Volume: 25(4)
Pages: 357-74
Peer Reviewed
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