Regulation of hepcidin expression in renal failure-participation of erythropoiesis related factor-

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590966
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: TOMOSUGI Naohisa Kanazawa Medical University, 付置研究所, 教授 (80155580)
• Project Period (FY): 2008 – 2010
• Keywords: ヘプシジン-25 / 骨髄造血機能 / 骨髄造血由来因子

Research Abstract

In this study, serum hepcidin-25, which is the regulator of the iron-metabolism, has been measured by mass spectrometry, and has became a molecular biomarker of erythropoietic disorders including renal anemia、iron overload and inflammation. The characteristics of iron-metabolism are to recycle iron in the closed system without an active iron-excretion system, and to keep the concentration of the serum iron. This is managed with the feed back mechanism based on the transferring receptor2-hepcidin-ferroportin system.

Research Products

• [Journal Article] Patients with chronic hepatitis C may be more sensitive to iron hepatotoxicity than patients with HFE-hemochromatosis. (2010)
  • Author(s): Hayashi H, Piperno A, Tomosugi N, Hayashi K, Kimura F, Wakusawa S, Yano M, Tatsumi Y, Hattori A, Pelucchi S, Katano Y, Goto H.
  • Journal Title: Intern Med. 49(22) Pages: 2371-7
  • Peer Reviewed
• [Journal Article] Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. (2010)
  • Author(s): Kono S, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H.
  • Journal Title: Biochim Biophys Acta. 1802(11) Pages: 968-75
  • Peer Reviewed
• [Journal Article] Downregulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman's disease (MCD). (2010)
  • Author(s): Song SN, Tomosugi N, Kawabata H, Ishikawa T, Nishikawa T, Yoshizaki K.
  • Journal Title: Blood. 116(18) Pages: 3627-34
  • Peer Reviewed
• [Journal Article] Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders. (2010)
  • Author(s): Kaneko Y, Miyajima H, Piperno A, Tomosugi N, Hayashi H, Morotomi N, Tsuchida KI, Ikeda T, Ishikawa A, Ota Y, Wakusawa S, Yoshioka K, Kono S, Pelucchi S, Hattori A, Tatsumi Y, Okada T, Yamagishi M.
  • Journal Title: J Gastroenterol. 45(11) Pages: 1163-71
  • Peer Reviewed
• [Journal Article] Increased Hepcidin Production Impairs Iron Metabolism after Pancreatoduodenectomy. (2010)
  • Author(s): Kosuge T, Sawada T, Shimoda M, Kita J, Tomosugi N, Kubota K.
  • Journal Title: World J Surg. 34(10) Pages: 2452-6
  • Peer Reviewed
• [Journal Article] Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. (2010)
  • Author(s): Hashizume M, Uchiyama Y, Horai N, Tomosugi N, Mihara M.
  • Journal Title: Rheumatol Int. 30 Pages: 917-923
  • Peer Reviewed
• [Journal Article] Results of the first international round robin for the quantification of urinary and plasma hepcidin assays : need for standardization. (2009)
  • Author(s): Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW.
  • Journal Title: Haematologica. 94 Pages: 1748-1752
  • Peer Reviewed
• [Journal Article] Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines. (2009)
  • Author(s): Kanda J, Uchiyama T, Tomosugi N, Higuchi M, Uchiyama T, Kawabata H.
  • Journal Title: Int J Hematol. 90 Pages: 545-552
• [Journal Article] Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation. (2008)
  • Author(s): Kanda J, Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Matsuo K, Uchiyama T.
  • Journal Title: Haematologica. 93(10) Pages: 1550-4
  • Peer Reviewed
• [Journal Article] Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. (2008)
  • Author(s): Fujita N, Sugimoto R, Motonishi S, Tomosugi N, Tanaka H, Takeo M, Iwasa M, Kobayashi Y, Hayashi H, Kaito M, Takei Y.
  • Journal Title: J Hepatol. 49(5) Pages: 702-10
  • Peer Reviewed
• [Presentation] 腎性貧血ガイドライン達成を目指す貧血管理ヘプシジン-25による新しい観点 (2010)
  • Author(s): 友杉直久
  • Organizer: 第54回日本透析医学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 20100618-20100620
• [Presentation] 保存期CKD患者における腎性貧血に与える血清インドキシル硫酸の影響の横断的検討 (2010)
  • Author(s): 勝二達也,友杉直久,植畑拓也,川端裕彰,新畑覚也,坂口悠介,下村明弘,鈴木朗,金子哲也,椿原美治
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 20100616-20100618
• [Presentation] Elevation of serum hepcidin 25 levels is well correlated with the progression of renal anemia in the peritoneal dialysis patients. (2009)
  • Author(s): Okubo K, Higuchi M, Kamijo Y, Nagasawa M, Tamura K, Tomosugi N
  • Organizer: ASN Renal Week 2009
  • Place of Presentation: San Diego, CA
  • Year and Date: 20091027-20091111
• [Presentation] TfR2-related hereditary hemochro-matosis in Japan. (2009)
  • Author(s): Mizumoto C, Kanda J, Kawabata H, Uchiyama T, Kojima K, Hayashi T, Hirata M, Nakao K, Tsuchida K, Kawanaka M, Yamada G, Tomosugi N, Tatsumi Y, Hattori A, Hayashi H.
  • Organizer: 2009 International Biolron Society
  • Place of Presentation: Porto, Portugal
  • Year and Date: 20090607-20090611
• [Presentation] 透析患者における貧血 発症メカニズムと病態 ヘプシジン-25と骨髄造血機能 (2009)
  • Author(s): 友杉直久
  • Organizer: 第54回日本透析医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20090605-20090607
• [Presentation] Clinical Significance of Serum Hepcidin-25 Levels on Early Treatment-Related Complications after Hematopoietic Stem Cell Transplantation (2008)
  • Author(s): Junya Kanda, Chisaki Mizumoto, Hiroshi Kawabata, Tatsuo Ichinohe, Hideyuki Tsuchida, Tomosugi N, Keitaro Matsuo, Tadakazu Kondo, Takayuki Ishikawa, Takashi Uchiyama.
  • Organizer: 50^<th> ASH Annual Meeting
  • Place of Presentation: San Francisco, CA
  • Year and Date: 20081206-20081209
• [Presentation] Results of the First International Round Robin for the Quantification of Urinary and Plasma Hepcidin : Need for Standardization (2008)
  • Author(s): Joyce JC Kroot, Erwin HJM Kemna, Sukhvinder Bansal, Mark Busbridge, Vatascia Campostrini, Domenico Girelli, Robert C Hider, Vasiliki Koliaraki, Avgi Mamalaki, Gordana Olbina, Naohisa Tomosugi, Chris Tselepis, Douglas G Ward, Tomas Ganz, Jan CM Hendriks, Dorine W. Swinkels.
  • Organizer: 50^<th> ASH Annual Meeting
  • Place of Presentation: San Francisco, CA
  • Year and Date: 20081206-20081209
• [Presentation] Identification and quantification of tear proteins in Sjogren's syndrome. (2008)
  • Author(s): Tomosugi N, H.Tuchida, M.Higuchi, H.Sasaki, K.Kitagawa.
  • Organizer: HUP02008 7th World Congeress
  • Place of Presentation: Amsterdam, NL
  • Year and Date: 20080816-20080820
• [Presentation] 保存期腎不全患者におけるヘプシジンの検討 (2008)
  • Author(s): 植畑拓也、友杉直久,坂口悠介,下村明弘,井上和則,金子哲也,勝二達也,岡田倫之,椿原美治
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 20080530-20080601
• [Presentation] C型慢性肝炎にみられる鉄過剰状態へのhepcidinの関与 (2008)
  • Author(s): 藤田尚己,杉本龍亮,本西哲,田中淳一朗,別府徹也,浦和尚史,田中秀明,山本憲彦,小林由直,岩佐元雄,白木克哉,友杉直久,林久男,竹井謙之
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 20080508-20080510