2010 Fiscal Year Final Research Report
Effect of salt load on the intrarenal angiotensin activity and receptor-mediated prorenin system in kidney fibrosis
| Project/Area Number |
20590967
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hamamatsu University |
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Principal Investigator |
YAMAMOTO Tatsuo Hamamatsu University, 健康プロデュース学部, 教授 (30200819)
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| Co-Investigator(Renkei-kenkyūsha) |
HISHIDA Akira 浜松医科大学, 医学部, 教授 (70111812)
SUZUKI Hiroyuki 浜松医科大学, 医学部, 助教 (10452179)
ISHIDA Junko 浜松大学, 健康プロデュース学部, 助教 (50410501)
ODAMAKI Mari 浜松大学, 健康プロデュース学部, 教授 (00347387)
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| Research Collaborator |
HUANG Yanjie 浜松医科大学, 医学部, リサーチアシスタント (30535563)
ISAKI Taro 浜松医科大学, 医学部, リサーチアシスタント (20464125)
OGAWA Akashi 浜松医科大学, 医学部, 医員 (90467225)
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| Project Period (FY) |
2008 – 2010
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| Keywords | レニン・アンジオテンシン系 / 高塩分 / プロレニン / 腎線維化 |
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| Research Abstract |
Although activation of intrarenal renin angiotensin system (RAS) is involved in the progression of kidney fibrosis, it is unknown how salt load that suppresses circulating RAS aggravates kidney fibrosis. This study demonstrated that high salt intake increased the apical membranous transition of (pro)renin receptor in collecting ducts and connecting tubules, resulting in the increased binding of prorenin and renin proteins without concomitant renin mRNA expression, followed by non-proteolytic activation of prorenin and angiotensin II generation, with resultant worsening of renal fibrosis in chronic anti-thymocyte serum nephritis on high salt intake.
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[Journal Article] Reduction of transforming growth factor-β type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma2010
Author(s)
Fukasawa H, Yamamoto T, Fujigaki Y, Misaki T, Ohashi N, Takayama T, Mugiya S, Oda T, Uchida C, Kitagawa K, Hattori T, Suzuki S, Hayashi H, Ozono S, Kitagawa M, Hishida A
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Journal Title
Int.J.Cancer 127
Pages: 1517-1525
Peer Reviewed
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[Journal Article] Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats2009
Author(s)
Misaki T, Yamamoto T, Suzuki S, Fukasawa H, Togawa A, Ohashi N, Suzuki H, Fujigaki Y, Oda T, Uchida C, Kitagawa K, Hattori T, Kitagawa M, Hishida A
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Journal Title
Am.J.Pathol. 175
Pages: 74-83
Peer Reviewed
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[Journal Article] Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats2008
Author(s)
Ohashi N, Yamamoto T, Huang Y, Misaki T, Fukasawa F, Suzuki H, Togawa A, Suzuki S, Fujigaki Y, Nakagawa T, Nakamura Y, Suzuki F, Kitagawa M, Hishida A
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Journal Title
Am.J.Physiol.Renal Physiol. 295(5)
Pages: F1512-F1518
Peer Reviewed
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