2010 Fiscal Year Final Research Report

The gender difference in the mechanisms that control glomerular hemodynamics.

Research Project

Project/Area Number	20590968
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Kidney internal medicine
Research Institution	Kinki University
Principal Investigator	ARIMA Shuji Kinki University, 医学部, 准教授 (60323010)
Co-Investigator(Kenkyū-buntansha)	TANIYAMA Yoshihiro 近畿大学, 医学部, 講師 (70441079)
Project Period (FY)	2008 – 2010
Keywords	輸出入細動脈 / 性差 / 血管内皮機能 / 性ホルモン
Research Abstract	We found neither gender difference in the control mechanisms of glomerular hemodynamics nor in the vascular reactivity of renal arterioles. In addition, at least under our experimental conditions any sexual hormone did not exert significant vascular actions on renal arterioles. . In the present study, we could not establish but somewhat develop an experimental system to study the possible gender differences in renal medullary blood flow. We also tried to develop a culture system of vascular smooth muscle cells and endothelial cells of renal arterioles to study the detail cellular mechanisms underlying the physiological and/or pathophysiological glomerular hemodynamics.

(4 results)