2010 Fiscal Year Final Research Report
Investigation of neoangiogenesis and lymphangiogenesis in ultrafiltration failure of CAPD patients and establishment of a novel therapeutic approach
| Project/Area Number |
20590972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
YASUHIKO Ito Nagoya University, 医学系研究科, 寄附講座教授 (60402632)
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| Project Period (FY) |
2008 – 2010
|
| Keywords | 腹膜透析 / リンパ管新生 / 血管新生 / 線維化 / VEGF-C / CTGF |
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| Research Abstract |
Ultrafiltration failure (UFF) and peritoneal dysfunction are impotrtant complications of long-term peritoneal dialysis (PD). We investigated angiogenesis, Iymphangiogenesis and peritoneal fibrosis in UFF. We demonstrated that CTGF acts downstream of TGF-β and plays an important role in peritoneal fibrosis, and that CTGF concentrations in PD effluent might be a biomarker of peritoneal function. We showed that increase of VEGF-C production and lymphangiogenesis in peritoneum are associated with UFF. VEGF-C is produced mainly by peritoneal mesothelial cells through TGF-β-VEGF-C pathway. Suppression on the TGF-β-CTGF and -VEGF-C pathway might be effective to regulate the peritoneal fibrosis and increase of peritoneal permeability.
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