2010 Fiscal Year Final Research Report
Molecular Regulation of bone-blood vessel type phosphate channel
| Project/Area Number |
20590975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ITO Mikiko The University of Tokushima, 環境人間学部・環境人間学科, 准教授 (50314852)
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| Research Collaborator |
MIYAMOTO Ken-Ichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (70174208)
SEGAWA Hiroko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70325257)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 人工透析 / リン / カルシウム / 異所性石灰化 / 破骨細胞 |
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| Research Abstract |
The hyperphosphatemia is observed at high ratio in the hemodialysis patients, and the phosphate (Pi) management is important because this leads of one's death by the cardiovascular disease by the ectopic calcification. Especially, Pi sensor and Pi channel are key protein to clear the ectopic calcification in bone. In this research, we tried to clarify the calcification mechanism by characterization of the Pi channel in the bone and/or the vascular endothelial. In this research, we indicated the molecular regulation of Pi channel and important role of the ectopic calcification.
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[Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis.2011
Author(s)
Tanimura A, Yamada F, Saito A, Ito M, Kimura T, Anzai N, Horie D, Yamamoto H, Miyamoto K, Taketani Y, Takeda E.
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Journal Title
J Med Invest. 58(1-2)
Pages: 140-147
Peer Reviewed
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[Journal Article] Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.2010
Author(s)
Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami F, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto K.
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Journal Title
Am J Physiol Renal Physiol. 298(6)
Pages: F1341-F1350
Peer Reviewed
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[Journal Article] An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.2010
Author(s)
Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, Sugino S, Uehata Y, Kamahara A, Sakata M, Tatsumi S, Kuwahata M, Taketani Y, Segawa H, Miyamoto KI
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Journal Title
Am J Physiol Renal Physiol. 299(1)
Pages: F243-F254
Peer Reviewed
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[Journal Article] Fibroblast growth factor 23 mediates the phosphaturic actions of cadmium.2010
Author(s)
Aranami F., Segawa H., Furutani J., Kuwahara S., Tominaga R., Hanabusa E., Tatsumi S., Kido S., Ito M., Miyamoto K.
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Journal Title
J Med Inv. 57(1,2)
Pages: 95-108
Peer Reviewed
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[Journal Article] Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.2009
Author(s)
Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K.
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Journal Title
Am J Physiol Renal Physiol. 297(3)
Pages: F671-F678
Peer Reviewed
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[Journal Article] Type IIc sodium-dependent phosphate transporter regulates calcium metabolism.2009
Author(s)
Segawa H, Onitsuka A, Kuwahata M, Hanabusa E, Furutani J, Kaneko I, Tomoe Y, Aranami F, Matsumoto N, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K.
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Journal Title
J Am Soc Nephrol. 20(1)
Pages: 104-113
Peer Reviewed
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[Presentation] Effect of Fibroblast Growth Factor (FGF) 23 on Npt2a,Npt2c Double-Knockout (WKO) Mice.2008
Author(s)
Y. Tomoe, H.Segawa, I. Kaneko, J. Furutani, H. Aranami, S. Kuwahara, R.Tominaga, E. Hnabusa, M.Ito, K.Miyamoto
Organizer
The American Society of Nephrology (ASN)
Place of Presentation
Philadelphia (USA)
Year and Date
20081108-20081113
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[Presentation] 無機リン酸代謝異常症の解明;リン酸トランスポートソームの構成タンパク質の膜移行シグナル2008
Author(s)
大井彰子, 伊藤美紀子, 櫻井文, 林敬治, 西山俊, 寒川奈津美, 杉野紗貴子, 上畑陽子, 辰巳佐和子, 瀬川博子, 宮本賢一
Organizer
第62回日本栄養・食糧学会
Place of Presentation
埼玉
Year and Date
2008-05-03
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[Book] リン酸トランスポーター関連分子群とリン代謝異常症,トランスレーショナルリサーチを支援する遺伝子医学MOOK(19)トランスポートソーム生体膜輸送機構の全体像に迫る-基礎,臨床,創訳応用研究の最新成果-2011
Author(s)
桑原頌治, 西山俊, 大井彰子, 金子一郎, 辰巳佐和子, 伊藤美紀子, 竹谷豊, 宮本賢一
Total Pages
244-248(274)
Publisher
メディカルドゥ社
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