2010 Fiscal Year Final Research Report
osteocyte has the role to lead calcium and phosphate to bone.
| Project/Area Number |
20590976
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TATSUMI Sawako The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (80420545)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Kenーichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (70174208)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リン / 骨細胞 / 腎臓 / 慢性腎臓病 / 人工透析 |
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| Research Abstract |
Recent studies have shown that alterations in osteocytes metabolism occur in very early stages of chronic renal disease (CKD) and likely mediate altered bone and mineral metabolism in patients with even very mild degree of renal dysfunction. In a previous study, we have established a transgenic mouse model, based on the diphtheria toxin (DT) receptor-mediated cell knockout (TRECK) system, in which inducible and specific ablation of osteocytes is achieved in vivo (Tatsumi S et al. Cell Metab 2007). "Osteocyte-ablated" mice exhibited excessive bone resorption, impaired mineralization and adipose tissue proliferation in marrow space, all of which are hallmarks of the ageing skeleton. To analysis the role of osteocyte in Pi homeostasis, we investigated renal Pi handling in the osteocyte-ablate mice. Plasma Pi and calcium concentration were not changed in the ablated mice. Plasma FGF23 levels were significantly decreased and plasma PTH levels were not changed in the ablated mice. Urinary Pi excretion was markedly increased and renal sodium dependent Pi cotransporter NaPi-IIa and NaPi-IIc protein levels were significantly decreased in the ablated mice. Thus, the osteocyte-ablated mice show increased renal Pi excretion. Osteocytes prevent renal phosphate loss.
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[Journal Article] An apical expression signal of the renal type IIc Na^+-dependent phosphate cotransporter in renal epithelial cells.2010
Author(s)
Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, Sugino S, Uehata Y, Kamahara A, Sakata M, Tatsumi S, Kuwahata M, Taketani Y, Segawa H, Miyamoto KI
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Journal Title
Am J Phisiol Renal Phisiol. 299(1)
Pages: 243-254
Peer Reviewed
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[Journal Article] Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.2010
Author(s)
Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami F, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto KI
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Journal Title
Am J Physiol Renal Physiol. 298(6)
Pages: 1341-1350
Peer Reviewed
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[Presentation] 腸管とリン代謝2010
Author(s)
宮本賢一, 花房悦世, 辰巳佐和子, 木戸慎介, 瀬川博子
Organizer
第28回日本骨代謝学会学術集会7/21-23
Place of Presentation
東京
Year and Date
20100000
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[Presentation] 新規リン利尿因子の探索2010
Author(s)
野村憲吾, 辰巳佐和子, 菊井聡子, 斎藤友紀子, 塩崎雄治, 山口誠一, 木戸慎介, 宮本賢一
Organizer
第64回日本栄養・食糧学会大会5/21-23(22)
Place of Presentation
徳島
Year and Date
20100000
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[Presentation] klotho Modulates the Activity of Type 11c Na^+-Dependent Phosphate Cotransporter (NaPi-11c) in Renal Epithelial Cells.2009
Author(s)
Takashi Nishiyama, Mikiko Ito, Akiko Ohi, Sakiko Sugino, Ishiro Kaneko, Masae Sawako, Akihiro Kamahara, Shinsuke Kido, Sawako Tatsumi, Hiroko Segawa, Keni-ichi Miyamoto
Organizer
The American Society of Nephrology (ASN) San Diego Convention Center 10/27-11/1(30)
Place of Presentation
San Diego, CA, USA
Year and Date
20090000
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[Presentation] Characterization of Phosphate Metabolism in the NaPi-11b Hetero Knockout Mice.2009
Author(s)
Etsuyo Hanabusa, Otoya Ueda, Hiroko Segawa, Ichiro Kaneko, Shoji Kuwahata, Sawako Tatsumi, Shuichi Ohtomo, Naoshi Horiba, Takanori Tachibe, Naoko Wada, Yousuke Kawase, Kou-ichi Jishage, Naoshi Fukushima, Keni-ichi Miyamoto
Organizer
The American Society of Nephrology (ASN) San Diego Convention Center 10/27-11/1(30)
Place of Presentation
San Diego, CA, USA
Year and Date
20090000
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[Presentation] Mutation of Type IIc Na^+ -Dependent Phosphate Cotransporter (NaPi-IIc) and Hereditary Hypophosphatemic Rickets with Hyper calci uria (HHRH)2008
Author(s)
Mikiko Ito, Aya Sakurai, Akiko Ohi, Keiji Hayashi, Takashi Nishiyama, Natsumi Kangawa, Sakiko Sugino, Sawako Tatsumi, Hiroko Segawa, Kenichi Miyamoto
Organizer
The American Society of Nephrology (ASN) , Pennsylvania Convention Center 11/4-9 (7)
Place of Presentation
Philadelphia Pennsylvania.
Year and Date
20080000
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[Book] リン酸トランスポーター関連分子群とリン代謝異常症,(トランスレーショナルリサーチを支援する遺伝子医学MOOK(19)トランスポートソーム生体膜輸送機構の全体像に迫る-基礎,臨床,創訳応用研究の最新成果-)2011
Author(s)
桑原頬治, 西山俊, 大井彰子, 金子一郎, 辰巳佐和子, 伊藤美紀子, 竹谷豊, 宮本賢一
Total Pages
244-248
Publisher
メディカルドゥ社
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[Remarks] ホームページ等 なし
