2010 Fiscal Year Final Research Report
Identifications for molecular mechanisms of essential hypertension in terms of urinary tubular ion transporter and human NEDD4L.
Project/Area Number |
20590978
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Yokohama City University |
Principal Investigator |
ISHIGAMI Tomoaki Yokohama City University, 医学部, 准教授 (50264651)
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Project Period (FY) |
2008 – 2010
|
Keywords | 尿細管 / ナトリウム輸送 / Nedd4L / 本態性高血圧症 / 心腎連関 |
Research Abstract |
Nedd4L has been paid attention for its unique ubiquitinating properties that does an important working to cuticle sodium channel (ENaC) in the tubular epithelial cell and the post-transcriptional modification so far. Clarification and study results of the urinary tubular sodium re-absorption mechanism, and the role of Nedd4L in cardio-renal relationship is examined and the research announcement is done.
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[Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.2010
Author(s)
Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga A, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S.
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Journal Title
Am J Physiol Renal Physiol. 299(5)
Pages: F991-F1003
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[Journal Article] Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy.2010
Author(s)
Masuda S, Tamura K, Wakui H, Maeda A, Dejima T, Hirose T, Toyoda M, Azuma K, Ohsawa M, Kanaoka T, Yanagi M, Yoshida S, Mitsuhashi H, Matsuda M, Ishigami T, Toya Y, Suzuki D, Nagashima Y, Umemura S.
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Journal Title
Am J Physiol Renal Physiol. 299(4)
Pages: F720-31
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[Journal Article] Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice.2010
Author(s)
Wakui H, Tamura K, Tanaka Y, Matsuda M, Bai Y, Dejima T, Masuda S, Shigenaga A, Maeda A, Mogi M, Ichihara N, Kobayashi Y, Hirawa N, Ishigami T, Toya Y, Yabana M, Horiuchi M, Minamisawa S, Umemura S.
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Journal Title
Hypertension 55(5)
Pages: 1157-1164
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[Journal Article] Blood pressure variability as well as blood pressure level is important for left ventricular hypertrophy and brachial-ankle pulse wave velocity in hypertensives.2009
Author(s)
Ozawa M, Tamura K, Okano Y, Matsushita K, Ikeya Y, Masuda S, Wakui H, Dejima T, Shigenaga A, Azuma K, Ishigami T, Toya Y, Ishikawa T, Umemura S.
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Journal Title
Clin Exp Hypertens. 31(8)
Pages: 669-679
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[Journal Article] Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis.2009
Author(s)
Mitsuhashi H, Tamura K, Yamauchi J, Ozawa M, Yanagi M, Dejima T, Wakui H, Masuda S, Azuma K, Kanaoka T, Ohsawa M, Maeda A, Tsurumi-Ikeya Y, Okano Y, Ishigami T, Toya Y, Tokita Y, Ohnishi T, Umemura S.
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Journal Title
Atherosclerosis 207(1)
Pages: 186-190
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[Journal Article] Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L.2009
Author(s)
Araki N, Ishigami T, Ushio H, Minegishi S, Umemura M, Miyagi Y, Aoki I, Morinaga H, Tamura K, Toya Y, Uchino K, Umemura S.
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Journal Title
Biochem Biophys Res Commun. 388(2)
Pages: 290-296
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[Journal Article] Identification of an increased short-term blood pressure variability on ambulatory blood pressure monitoring as a coronary risk factor in diabetic hypertensives.2009
Author(s)
Ozawa M, Tamura K, Okano Y, Matsushita K, Yanagi M, Tsurumi-Ikeya Y, Oshikawa J, Hashimoto T, Masuda S, Wakui H, Shigenaga A, Azuma K, Ishigami T, Toya Y, Ishikawa T, Umemura S.
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Journal Title
Clin Exp Hypertens. 31(3)
Pages: 259-270
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[Journal Article] Effects of angiotensin II type 1 receptor blocker on blood pressure variability and cardiovascular remodeling in hypertensive patients on chronic peritoneal dialysis.2009
Author(s)
Shigenaga A, Tamura K, Dejima T, Ozawa M, Wakui H, Masuda S, Azuma K, Tsurumi-Ikeya Y, Mitsuhashi H, Okano Y, Kokuho T, Sugano T, Ishigami T, Toya Y, Uchino K, Tokita Y, Umemura S.
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Journal Title
Nephron Clin Pract. 112(1)
Pages: c31-c40
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