2010 Fiscal Year Final Research Report
Experimental study for the regression of chronic kidney disease and mineral bone disorder(CKD-MBD)
| Project/Area Number |
20590985
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
AKIZAWA Tadao Showa University, 医学部, 教授 (40102339)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGATA Hiroaki 昭和大学, 医学部, 講師 (30296959)
MIZOBUCHI Masahide 昭和大学, 医学部, 助教 (90465203)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 慢性腎臓病ミネラル骨代謝異常症 / 二次性副甲状腺機能亢進症 / 腎性骨異栄養症 / 異所性石灰化 / 慢性炎症 / エラスチン |
|---|
| Research Abstract |
To regress the pathological findings resulted from chronic kidney disease mineral and bone disorder (CKD-MBD), it may be effective to directly inject the active vitamin D or its analogue into parathyroid gland and to systemically administrate vitamin D and/or calcimimetics for enlarged parathyroid gland and high turn-over bone disease. But it is difficult to regress ectopic vascular calcification by these methods. It may be important to prevent inflammatory process and elastin degradation for regression. Further studies are urgently required to clarify this point.
|
-
-
-
-
[Journal Article] Impact of fibroblast growth factor 23 on lipids and atherosclerosis in hemodialysis patients.2010
Author(s)
Ashikaga E, Honda H, Suzuki H, Hosaka N, Hirai Y, Sanada D, Nakamura M, Nagai H, Matsumoto K, Kato N, Mukai M, Watanabe M, Takahashi K, Shishido K, Akizawa T.
-
Journal Title
Ther Apher Dial. 14(3)
Pages: 315-22
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Mortality risk for dialysis patients with different levels : the Dialysis Outcomes and Practice Patterns Study (DOPPS).2008
Author(s)
Tentori F, Blayney MJ, Albert JM, Gillespie BW, Kerr PG, Bommer J, Young EW, Akizawa T, Akiba T, Pisoni RL, Robinson BM, Port FK
-
Journal Title
Am J Kidney Dis. 52(3)
Pages: 519-30
Peer Reviewed
-
-
-
-
-
-
