2010 Fiscal Year Final Research Report
Development of new treatments for Crow-Fukase syndrome
| Project/Area Number |
20590988
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
KUWABARA Satoshi Chiba University, 大学院・医学研究院, 教授 (70282481)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masahiro 千葉大学, 大学院・医学研究院, 講師 (70345023)
KANAI Kazuaki 千葉大学, 医学部附属病院, 助教 (10375751)
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| Project Period (FY) |
2008 – 2010
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| Keywords | クロウ・深瀬症候群 / 自己末梢血幹細胞移植 / サリドマイド |
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| Research Abstract |
POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome is potentially fatal disease, and patients' quality of life deteriorates because of progressive neuropathy. The aim of this study was to clarify the effects of (1) high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) and thalidomide therapy. PBSCT was performed in 21 patients under age 66 years, and resulted in obvious improvement in neuropathy as well as other symptoms. Fifteen patients aged 66 years or older received thalidomide, resulting in moderate clinical improvement (n=12) and stabilization of symptoms (n=3). Based on the findings, we proposed a treatment guideline with PBSCT or thalidomide therapy according to patients' age.
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[Journal Article] Successful combination treatment with bevacizumab, thalidomide and autologous PBSC for severe POEMS syndrome.2009
Author(s)
Ohwada C, Nakaseko C, Sakai S, Takeda Y, Abe D, Takeuchi M, Sakaida E, Masuda S, Shimizu N, Cho R, Nishimura M, Kanai K, Misawa S, Kuwabara S.
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Journal Title
Bone Marrow Transplant 43(9)
Pages: 739-740
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[Journal Article] Restrictive usage of monoclonal immunoglobulin lambda light chain germline in POEMS syndrome.2008
Author(s)
Abe D, Nakaseko C, Takeuchi M, Tanaka H, Ohwada C, Sakaida E, Takeda Y, Oda K, Ozawa S, Shimizu N, Masuda S, Cho R, Nishimura M, Misawa S, Kuwabara S, Saito Y.
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Journal Title
Blood 112(3)
Pages: 836-839
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