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2010 Fiscal Year Final Research Report

A role of insulin signal impairment in the pathogenesis of Alzheimer disease

Research Project

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Project/Area Number 20590990
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNiigata University

Principal Investigator

IKEUCHI Takeshi  Niigata University, 脳研究所, 助教 (20372469)

Project Period (FY) 2008 – 2010
Keywordsアルツハイマー病 / 認知症 / 糖尿病 / インスリンシグナル伝達
Research Abstract

Insulin resistance caused by diabetes is now recognized as risk factor of Alzheimer disease (AD). We conducted a research to verify a role of insulin signal impairment in AD pathogenesis and here provide following findings. i) increase of insulin in culture medium leads to enhanced production of β-amyloid (Aβ). ii) overproduction of Aβ induces abnormal phosphorylation of tau, iii) insulin signal transduction is impaired by overproduction of Aβ. These findings suggest that heperinsulinemia may accelerates AD pathogenesis and insulin signal transduction may play a role in Aβ-induced tau phosphorylation.

  • Research Products

    (19 results)

All 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Dementia Geriat Cogn Disord2010

    • Author(s)
      Ikeuchi T, Hirayama S, Miida T, Fukamachi I, Tokutake T, Ebinuma H, Takubo K, Kaneko H, Kasuga K, Kakita A, Takahashi H, Bujo H, Saito Y, Nishizawa M.
    • Journal Title

      30

      Pages: 28-32

    • Peer Reviewed
  • [Journal Article] Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, parkinsonism and motor neuron disease : a distinct clinicopathological and biochemical disease entity.2010

    • Author(s)
      Fu Y, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao YS, Tan CF, Tani T, Koide R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H.
    • Journal Title

      Acta Neuropathologica 120

      Pages: 21-32

    • Peer Reviewed
  • [Journal Article] Differential levels of α-synuclein, β-amyloid, and tau in cerebrospinal fluid between patients with dementia with Lewy bodies and Alzheimer disease.2010

    • Author(s)
      Kasuga K, Tokutake T, Ishikawa A, Uchiyama T, Tokuda T, Onodera O, Nishizawa M, Ikeuchi T.
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry 81

      Pages: 608-610

    • Peer Reviewed
  • [Journal Article] Alzheimer's disease : Report of two autopsy cases with a clinical diagnosis of corticobasal degeneration.2010

    • Author(s)
      Okazaki K, Fu Y-J, Nishihira Y, Endo M, Fukushima T, Ikeuchi T, Okamoto K, Onodera O, Nishizawa M, Takahashi H.
    • Journal Title

      Neuropathology 30

      Pages: 140-148

    • Peer Reviewed
  • [Journal Article] Depression and psychiatric symptoms preceding onset of dementia in family with early-onset Alzheimer disease with novel PSEN1-mutation.2009

    • Author(s)
      Kasuga K, Ohno T, Ishihara T, Miyashita A, Kuwano R, Onodera O, Nishizawa M, Ikeuchi T.
    • Journal Title

      Journal of Neurology 256

      Pages: 1351-1353

    • Peer Reviewed
  • [Journal Article] Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease.2009

    • Author(s)
      Kasuga K, Shimohata T, Nishimura A, Shiga A, Mizuguchi T, Tokunaga J, Ohno T, Miyashita A, Kuwano R, Matsumoto N, Onodera O, Nishizawa M, Ikeuchi T.
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry 80

      Pages: 1050-1052

    • Peer Reviewed
  • [Journal Article] The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system.2009

    • Author(s)
      Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S,T Arai T, Ikeuchi T, Kasuga K, Tokuda T, Masaki Kondo M, Masaki Ikeda M, Kentaro Deguchi K, Hiroaki Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
    • Journal Title

      EMBO Molecular Medicine 1

      Pages: 223-235

    • Peer Reviewed
  • [Presentation] レビー小体型認知症(DLB)の新規バイオマーカー:髄液αシヌクレインのELISA定量2010

    • Author(s)
      徳武孝允, 春日健作, 矢島隆二, 石川厚, 内山剛, 徳田隆彦, 西澤正豊, 池内健
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
  • [Presentation] アルツハイマー病患者・髄液中では可溶性LR11が増加する2010

    • Author(s)
      池内健, 平山哲, 三井田孝, 深町勇, 矢島隆二, 徳武孝允, 春日健作, 金子博之, 田久保耕平, 海老沼宏幸, 武城英明, 西澤正豊
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
  • [Presentation] APOEε4(+)群とε4(-)群との臨床経過,側頭葉内側部萎縮,髄液バイオマーカーの比較2010

    • Author(s)
      矢島隆二, 池内健, 春日健作, 徳武孝允, 西澤正豊
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
  • [Presentation] 健忘主体の臨床徴候を呈するタウ遺伝子R406W変異を伴う家族性認知症2010

    • Author(s)
      池内健, 春日健作, 宮下哲典, 川瀬康裕, 杉下守弘, 桑野良三, 西澤正豊
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-20
  • [Presentation] βアミロイド依存性タウリン酸化カスケードにおけるインスリンシグナル障害の関与2010

    • Author(s)
      徳武孝允, 池内健, 春日健作, 篠崎真, 小野寺理, 西澤正豊
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
  • [Presentation] アルツハイマー病関連・βアミロイド(Aβ)配列内変異がAβ産生および高次構造に及ぼす影響2009

    • Author(s)
      篠崎真, 金子博之, 春日健作, 徳武孝允 ,小野寺理, 西澤正豊, 池内健
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
  • [Presentation] 健忘主体の特異な臨床型を呈したタウ遺伝子(MAPT)R406W変異を伴う家族性認知症の臨床分子遺伝子学的解析2009

    • Author(s)
      池内健, 春日健作, 宮下哲典, 川瀬康裕, 小野寺理, 杉下守弘, 桑野良三, 西澤正豊
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-21
  • [Presentation] レビー小体の大脳皮質におけるαシヌクレイン蓄積とSNCAmRNA発現の検討2009

    • Author(s)
      野崎洋明, 石平悠, 金子博之, 豊島靖子, 柿田明美, 高橋均, 小野寺理, 西澤正豊, 池内健
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-21
  • [Presentation] Aβはインスリンシグナルを障害することでタウの過剰リン酸化を引き起こすか?2009

    • Author(s)
      春日健作, 徳武孝允, 篠崎真, 西澤正豊, 小野寺理, 池内健
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-20
  • [Presentation] 認知症性疾患の髄液バイオマーカーとしてのαシヌクレインの検討2009

    • Author(s)
      春日健作, 池内健, 石川厚, 徳田隆彦, 中川正法, 小野寺理, 西澤正豊
    • Organizer
      第50回日本神経学会口演発表
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-24
  • [Presentation] 遺伝子変異を伴った家族性アルツハイマー病の表現形の比較2009

    • Author(s)
      池内健, 春日健作, 野崎洋明, 石原智彦, 金子博之, 篠崎真, 桑野良三, 小野寺理, 西澤正豊
    • Organizer
      第50回日本神経学会口演発表
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-22
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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