2010 Fiscal Year Final Research Report
Possible pathomechanism of multiple sclerosis from the perspective of abnormal mucosal immune responses
| Project/Area Number |
20590991
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
KAWACHI Izumi Niigata University, 医歯学総合病院, 助教 (40432083)
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| Co-Investigator(Kenkyū-buntansha) |
TOYOSHIMA Yasuko 新潟大学, 脳研究所, 助教 (20334675)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 中枢神経系脱髄疾患 / 多発性硬化症 / 視神経脊髄炎 / 粘膜免疫 / innate T細胞 / interleukin-17 / 衛生仮説 |
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| Research Abstract |
The prevalence of multiple sclerosis (MS) and Crohn's disease have increased since 1960s in Japan. The 'hygiene hypothesis' has been proposed for immunopathogenesis of MS. The distinct population of double negative T cells (DNT) expressing IL-17 was identified in patients with MS. As most of DNT cells are composed of innate T cells including γδT cells and IL-17-expressing cells are most abundant at steady state in gut-associated tissues, we suspect that the production of IL-17 derived from mucosal associated cells including not only T_H-17 per se but also innate T cells might be critical elements contributing to MS.
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