Transplantation of vascular progenitor cells derived from human ES cells in a mouse model of chronic cerebral hypoperfusion

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590996
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Mie University
• Principal Investigator: TOMIMOTO Hidekazu Mie University, 大学院・医学系研究科, 教授 (80324648)
• Research Collaborator: WASHIDA Kazuo 京都大学, 大学院・医学研究科神経内科, 大学院生
• Project Period (FY): 2008 – 2010
• Keywords: 慢性脳虚血 / 血管前駆細胞 / 胚性幹細胞 / 人工多能性幹細胞

Research Abstract

Vascular progenitor cells (VPC)derived from human iPS cells were transplanted into thestriatum or cerebral cortex in a mouse model of chronic cerebral hypoperfusion, or sham-operation. Vessel-like structure were found exclusively in the striatum of the mice subjected to chronic cerebral hypoperfusion. In the striatum under chronic cerebral ischemia, there may be some factors to facilitate survival of VPC.

Research Products

• [Journal Article] Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice. (2011)
  • Author(s): Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H, Harada H, Yokoi H, Arai H, Itch H, Nakao K, Takahashi R, Tomimoto H
  • Journal Title: Stroke 42 Pages: 1122-1128
  • Peer Reviewed
• [Journal Article] Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion. (2010)
  • Author(s): Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
  • Journal Title: Stroke 41 Pages: 1798-1806
  • Peer Reviewed
• [Journal Article] A mouse model characterizing features of vascular dementia with hippocampal atrophy. (2010)
  • Author(s): Nishio K, Thara M, Yamasaki N, Kalaria RN, Makia T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H
  • Journal Title: Stroke 41(6) Pages: 1278-1284
  • Peer Reviewed
• [Journal Article] Chronic cerebral hypoperfusion accelerates amyloid deposition in APPSwInd transgenic mice. (2009)
  • Author(s): Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, Kihara T, Asada-UtsugiM, Kinoshita A, Takahashi R.
  • Journal Title: Brain Research 1294 Pages: 202-210
  • Peer Reviewed
• [Journal Article] 脳血管性認知症の分子病態 (2008)
  • Author(s): 鷲田和夫、猪原匡史、冨本秀和
  • Journal Title: Medical Science Digest 34 Pages: 391-394
• [Presentation] マウス慢性脳低灌流モデルに対する血管前駆細胞移植の効果 (2009)
  • Author(s): 鷲田和夫, 猪原匡史, 高橋淳, 山下潤, 伊東秀文, 冨本秀和, 高橋良輔
  • Organizer: 日本神経学会総会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-05-20