Analyses of responsible protein for familial Parkinson's disease in lipid rafts.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: KUBO Shinichiro Juntendo University, 医学研究科, 准教授 (20327795)
• Project Period (FY): 2008 – 2010
• Keywords: 家族性パーキンソン病

Research Abstract

It is unknown how mutant proteins responsible for familial Parkinson's disease result in nigral degeneration as well as where these protein localize in neuronal cells. We have revealed that LRRK2, in addition to alpha-synuclein and parkin, associates with lipid rafts, microdomains of cell membranes which play important roles in signal transduction and membrane trafficking in the cell. We have, furthermore, found membrane-binding potentials of DJ-1 and PINK1 proteins.

Research Products

• [Journal Article] Effective control of catatonia in Parkinson's disease by electroconvulsive therapy : a case report. (2009)
  • Author(s): Kamigaichi R, Kubo S, Ishikawa K, Yokoyama K, Ogaki K, Usui C, Hatta K, Arai H, Mochizuki H, Hattori N
  • Journal Title: Eur J Neurol 16 Pages: e6
• [Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism : screening strategy in parkinsonism. (2009)
  • Author(s): Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N
  • Journal Title: Neurosci Lett 455 Pages: 159-161
• [Journal Article] Parkin stabilizes PINK1 through direct interaction. (2009)
  • Author(s): Shiba K, Arai T, Sato S, Kubo S, Ohba Y, Mizuno Y, Hattori N
  • Journal Title: Biochem Biophys Res Commun 383 Pages: 331-335
• [Journal Article] Unmet needs of patients with Parkinson's disease : interview survey of patients and caregivers. (2009)
  • Author(s): Hatano T, Kubo S, Shimo Y, Nishioka K, Hattori N
  • Journal Title: J Int Med Res 37 Pages: 717-726
• [Journal Article] Visual impairment in Parkinson's disease treated with amantadine : Case report and review of the literature. (2008)
  • Author(s): Kubo S, Iwatake A, Ebihara N, Murakami A, Hattori N
  • Journal Title: Parkinsonism Relat Disord 14 Pages: 166-169
• [Journal Article] Familial Parkinsonism with digenic parkin and PINK1 mutations. (2008)
  • Author(s): Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, Mizuno Y, Hattori N
  • Journal Title: Mov Disord 23 Pages: 1461-1465
• [Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease. (2008)
  • Author(s): Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo S, Mizuno Y, Toda T, Hattori N
  • Journal Title: J Hum Genet 53 Pages: 1012-1015
• [Presentation] PINK1 binds to cellular membrane. (2008)
  • Organizer: The Movement Disorder Society.
  • Place of Presentation: Chicago
  • Year and Date: 2008-06-24
• [Presentation] Possible localization of DJ-1 on the plasma membrane in the mouse brain and cultured cell lines. (2008)
  • Organizer: The Movement Disorder Society.
  • Place of Presentation: Chicago
  • Year and Date: 2008-06-24
• [Book] パーキンソン病診療Q&A110(水野美邦)(Q67. 1日300mg以上の塩酸アマンタジンがジスキネジアを抑制するといわれますが、同じ薬物が維持量の違いによってパーキンソニズムに効いたり、ジスキネジアに効いたりする機序は何なのでしょうか?) (2009)
  • Author(s): 久保紳一郎
  • Total Pages: 205-209
  • Publisher: 中外医学社,東京
• [Book] パーキンソン病Q&A(服部信孝)(Q2.パーキンソン病の原因は?) (2009)
  • Author(s): 久保紳一郎
  • Total Pages: 5-8
  • Publisher: 日本医事新報社,東京
• [Book] 医学のあゆみ(ここまでわかったパーキンソン病研究 医歯薬出版別冊) (2008)
  • Author(s): 河尻澄宏、久保紳一郎
  • Total Pages: 100
• [Remarks] ホームページ等