2010 Fiscal Year Final Research Report
Elucidation of pathogenesis of interleukin-17-producing T cells in multiple sclerosis
| Project/Area Number |
20591014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
ARANAMI Toshimasa National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 組織培養研究室長 (60435724)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 多発性硬化症 / T細胞分化 / インターロイキン17 |
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| Research Abstract |
Using simultaneous staining of four chemokine receptors, we identified a unique T cell population increased in the cerebrospinal fluid of patients with relapsing multiple sclerosis. CCR2+CCR5+ T cells were selectively enriched in the cerebrospinal fluid of multiple sclerosis patients but not of patients with other inflammatory and non-inflammatory neurological diseases. We found that CCR2+CCR5+ T cells from peripheral blood of multiple sclerosis patients in relapse specifically responded to myelin basic protein and produced both interferon-γ and interleukin-17. Of note, we demonstrated that the CCR2+CCR5+ population possesses a distinct ability to produce matrix metalloproteinase-9 and osteopontin, both of which are thought to be crucial for the invasion into the parenchyma. We propose that the CCR2+CCR5+ T cells may play a role in triggering brain autoimmune inflammation.
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