Pathophysiology of Parkison disease : a review of cortico-basal ganglia loop model

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591023
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: SAWAMOTO Nobukatsu Kyoto University, 医学研究科, 助教 (90397547)
• Project Period (FY): 2008 – 2010
• Keywords: パーキンソン病 / 神経機能画像 / ドパミン / 大脳皮質基底核ループ

Research Abstract

In basal ganglia disorders, it is essential to clarify 'network dysfunction' in order to understand pathophysiological mechanisms from neuronal cell degeneration to clinical symptoms. Since the basal ganglia have no direct motor output, the network dysfunction should results in disordered outputs from the motor cortex reflecting the clinical symptoms. The present studies suggest that compensatory function of the cerebellum as well as disrupted function of cortico-basal ganglia loop should be considered in pathophydiological mechanisms of Parkinson disease.

Research Products

• [Journal Article] Alexithymia and regional gray matter alterations in schizophrenia. (2011)
  • Author(s): Kubota M, Miyata J, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Neurosci Res 印刷中
  • Peer Reviewed
• [Journal Article] Amygdalar enlargement in patients with temporal lobe epilepsy. (2011)
  • Author(s): Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N, Mikuni N, Fukuyama H, Takahashi R.
  • Journal Title: J Neurol Neurosurg Psychiatry 印刷中
  • Peer Reviewed
• [Journal Article] Age-related cortical thinning in schizophrenia. (2011)
  • Author(s): Kubota M, Miyata J, Yoshida H, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Murai T.
  • Journal Title: Schizophr Res 125 Pages: 21-29
  • Peer Reviewed
• [Journal Article] Task-irrelevant memory load induces inattentional blindness without temporo-parietal suppression. (2010)
  • Author(s): Matsuyoshi D, Ikeda T, Sawamoto N, Kakigi R, Fukuyama H, Osaka N.
  • Journal Title: Neuropsychologia 48 Pages: 3094-3101
  • Peer Reviewed
• [Journal Article] The neural correlates of endowment effect without economic transaction. (2010)
  • Author(s): Votinov M, Mima T, Aso T, Abe M, Sawamoto N, Shinozaki J, Fukuyama H.
  • Journal Title: Neurosci Res 68 Pages: 59-65
  • Peer Reviewed
• [Journal Article] Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia. (2010)
  • Author(s): Miyata J, Yamada M, Namiki C, Hirao K, Saze T, Fujiwara H, Shimizu M, Kawada R, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
  • Journal Title: Schizophr Res 119 Pages: 232-239
  • Peer Reviewed
• [Journal Article] Correlation between cognitive deficits and glucose hypometabolism in mild cognitive impairment. (2010)
  • Author(s): Nishi H, Sawamoto N, Namiki C, Yoshida H, Dinh HD, Ishizu K, Hashikawa K, Fukuyama H.
  • Journal Title: J Neuroimaging 20 Pages: 29-36
  • Peer Reviewed
• [Journal Article] Investigating association of brain volumes with intracranial capacity in schizophrenia. (2010)
  • Author(s): Ueda K, Fujiwara H, Miyata J, Hirao K, Saze T, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Murai T.
  • Journal Title: Neuroimage 49 Pages: 2503-2508
  • Peer Reviewed
• [Journal Article] 脳機能画像を用いた早期診断 (2010)
  • Author(s): 澤本伸克
  • Journal Title: 最新医学 65 Pages: 851-855
• [Journal Article] 特発性パーキンソン病鑑別診断へのポジトロン断層法の応用 (2010)
  • Author(s): 澤本伸克
  • Journal Title: Frontiers in Parkinson Disease 3 Pages: 36-38
• [Journal Article] Brain volume and dysexecutive behavior in schizophrenia. (2009)
  • Author(s): Kawada R, Yoshizumi M, Hirao K, Fujiwara H, Miyata J, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33 Pages: 1255-1260
  • Peer Reviewed
• [Journal Article] An intrinsic diffusion response function for analyzing diffusion functional MRI time series. (2009)
  • Author(s): Aso T, Urayama S, Poupon C, Sawamoto N, Fukuyama H, Le Bihan D.
  • Journal Title: Neuroimage 47 Pages: 1487-1495
  • Peer Reviewed
• [Journal Article] Water-diffusion slowdown in the human visual cortex on visual stimulation precedes vascular responses. (2009)
  • Author(s): Kohno S, Sawamoto N, Urayama S, Aso T, Aso K, Seiyama A, Fukuyama H, Le Bihan D.
  • Journal Title: J Cereb Blood Flow Metab 29 Pages: 1197-1207
  • Peer Reviewed
• [Journal Article] Spin-echo T1-weighted imaging of the brain with interleaved acquisition and presaturation pulse at 3 T : a feasibility study before clinical use. (2009)
  • Author(s): Kasahara S, Miki Y, Mori N, Urayama S, Kanagaki M, Fushimi Y, Maeda C, Sawamoto N, Fukuyama H, Togashi K.
  • Journal Title: Acad Radiol 16 Pages: 852-857
  • Peer Reviewed
• [Journal Article] Reduced white matter integrity correlated with cortico-subcortical gray matter deficits in schizophrenia. (2009)
  • Author(s): Miyata J, Hirao K, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
  • Journal Title: Schizophr Res 111 Pages: 78-85
  • Peer Reviewed
• [Journal Article] A novel composite targeting method using high-field magnetic resonance imaging for subthalamic nucleus deep brain stimulation. (2009)
  • Author(s): Toda H, Sawamoto N, Hanakawa T, Saiki H, Matsumoto S, Okumura R, Ishikawa M, Fukuyama H, Hashimoto N.
  • Journal Title: J Neurosurg 111 Pages: 737-45
  • Peer Reviewed
• [Journal Article] Susceptibility-weighted imaging at 3 Tesla delineates the optic radiation. (2009)
  • Author(s): Mori N, Miki Y, Kasahara S, Maeda C, Kanagaki M, Urayama S, Sawamoto N, Fukuyama H, Togashi K.
  • Journal Title: Invest Radiol 44 Pages: 140-145
  • Peer Reviewed
• [Journal Article] PETによる機能画像 (2009)
  • Author(s): 澤本伸克
  • Journal Title: 細胞 41 Pages: 137-139
• [Journal Article] Brooks DJ Cognitive deficits and striato-frontal dopamine release in Parkinson's disease. (2008)
  • Author(s): Sawamoto N, Piccini P, Hotton G, Pavese N, Thielemans K
  • Journal Title: Brain 131 Pages: 1294-1302
  • Peer Reviewed
• [Journal Article] The role of the uncinate fasciculus in memory and emotional recognition in amnestic mild cognitive impairment. (2008)
  • Author(s): Fujie S, Namiki C, Nishi H, Yamada M, Miyata J, Sakata D, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Journal Title: Dement Geriatr Cogn Disord 26 Pages: 432-439
  • Peer Reviewed
• [Journal Article] Female specific anterior cingulate abnormality and its association with empathic disability in schizophrenia. (2008)
  • Author(s): Fujiwara H, Shimizu M, Hirao K, Miyata J, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32 Pages: 1728-1734
  • Peer Reviewed
• [Journal Article] Theory of mind and frontal lobe pathology in schizophrenia : a voxel-based morphometry study. (2008)
  • Author(s): Hirao K, Miyata J, Fujiwara H, Yamada M, Namiki C, Shimizu M, Sawamoto N, Fukuyama H,Hayashi T, Murai T.
  • Journal Title: Schizophr Res 105 Pages: 165-174
  • Peer Reviewed
• [Journal Article] The presence of multiple microbleeds as a predictor of subsequent cerebral hemorrhage in patients with moyamoya disease. (2008)
  • Author(s): Kikuta K, Takagi Y, Nozaki K, Sawamoto N, Fukuyama H, Hashimoto N.
  • Journal Title: Neurosurgery 62 Pages: 104-112
  • Peer Reviewed
• [Journal Article] Hemispheric asymmetry of the arcuate fasciculus : a preliminary diffusion tensor tractography study in patients with unilateral language dominance defined by Wada test. (2008)
  • Author(s): Matsumoto R, Okada T, Mikuni N, Mitsueda-Ono T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Hashimoto N, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: J Neurol 255 Pages: 1703-1711
  • Peer Reviewed
• [Journal Article] Microbleeds in moyamoya disease : susceptibility-weighted imaging versus T2*-weighted imaging at 3 Tesla. (2008)
  • Author(s): Mori N, Miki Y, Kikuta K, Fushimi Y, Okada T, Urayama S, Sawamoto N, Fukuyama H, Hashimoto N, Togashi K
  • Journal Title: Invest Radiol 43 Pages: 574-579
  • Peer Reviewed
• [Presentation] Basal ganglia circuitry : Cognitive functions. (2010)
  • Author(s): 澤本伸克
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-01
• [Presentation] Diffusion MRI as a tool forneuroscience. (2010)
  • Author(s): 澤本伸克
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Organization for Human Brain Mapping (2010)
  • Author(s): Oguri T, Sawamoto N, Urayama S, Matsuhasi M, Ojika K, Fukuyama H
  • Organizer: 16th Annual Meeting
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2010-06-09
• [Presentation] Abnormal white matter asymmetry in schizophrenia demonstrated by tract-based spatial statistics. (2010)
  • Author(s): Miyata J, Kawada R, Fujimoto S, Tanaka Y, Fukuyama, Sawamoto N, Murai T
  • Organizer: Organization for Human Brain Mapping 16th Annual Meeting
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2010-06-07
• [Presentation] パーキンソン病の運動障害と基底核-補足運動野系との関連 (2010)
  • Author(s): 椨勇人、澤本伸克、小栗卓也、高橋良輔、福山秀直
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-22
• [Presentation] パーキンソン病患者のパーソナリティに関わる神経基盤についての検討 (2010)
  • Author(s): 澤本伸克、椨勇人、高橋良輔、福山秀直
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] ヒト随意運動における基底核-補足運動野系との関連:補足運動野は小脳より大脳基底核と強固な神経結合を保持している (2010)
  • Author(s): 小栗卓也、澤本伸克、椨勇人、浦山慎一、松橋眞生、小鹿幸生、福山秀直
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-21
• [Presentation] 依存の脳を観る (2010)
  • Author(s): 澤本伸克
  • Organizer: 依存学ことはじめ
  • Place of Presentation: 京都
  • Year and Date: 2010-03-14
• [Presentation] 機能画像からBraak仮説を考える (2010)
  • Author(s): 澤本伸克
  • Organizer: パーキンソン病基礎と臨床の最前線～Braak仮説を考える～
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] Pathophyisiology of Parkinson disease : neuroimaging approaches. (2010)
  • Author(s): 澤本伸克
  • Organizer: カン研究所講演会
  • Place of Presentation: 神戸
  • Year and Date: 2010-01-19
• [Presentation] Human supplementary motor area has stronger connectivity with the basal ganglia than cerebellum during movement. (2009)
  • Author(s): OGURI T, SAWAMOTO N, URAYAMA S, MATSUHASHI M, FUKUYAMA H
  • Organizer: Neuroscience 2009, Annual meeting of society for neuroscience
  • Place of Presentation: アメリカ、シカゴ
  • Year and Date: 2009-10-20
• [Presentation] Individual-based fMRI analysis of visual short-term memory mechanism in human intraparietal sulcus. (2009)
  • Author(s): KANAZU M, YAMAMOTO H, SAWAMOTO N, FUKUYAMA H, SAIKI J
  • Organizer: Neuroscience 2009, Annual meeting of society for neuroscience
  • Place of Presentation: アメリカ、シカゴ
  • Year and Date: 2009-10-20
• [Presentation] Basal ganglia dopamine and motor subtypes of Parkinson' s disease. (2009)
  • Author(s): Tabu H, Sawamoto N, Kawashima H, Ishizu K, Fukuyama H, Takahashi R
  • Organizer: Movement Disorder Society 13th International Congress
  • Place of Presentation: フランス、パリ
  • Year and Date: 2009-06-11
• [Presentation] 安静時振戦が優位な徴候であるパーキンソン病患者における基底核ドパミンの検討 (2009)
  • Author(s): 椨勇人、澤本伸克、河嶋秀和、石津浩一、福山秀直、高橋良輔
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-20
• [Presentation] 大脳半球深部白質の広範な拡散異方性低下がLeukoaraiosis患者の認知機能低下と相関する (2009)
  • Author(s): 大塚快信、山内浩、澤本伸克、井関一海、冨本秀和、福山秀直
  • Organizer: 第34回日本脳卒中学会総会
  • Place of Presentation: 島根
  • Year and Date: 2009-03-20
• [Presentation] 脳波と機能的MRIの同時計測(EEG-fMRI)によるてんかん焦点の同定と関連するネットワークの評価:皮質脳波との比較 (2008)
  • Author(s): 井内盛遠、松本理器、澤本伸克、中川朋一、浦山慎一、美馬達哉、三國信啓、穴見公隆、栗屋智就、加藤武雄、福山秀直、高橋良輔、池田昭夫
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-22
• [Presentation] Clinical application of a new technique to identify brain anatomical networks-probabilistic tractography. (2008)
  • Author(s): 松本敦仁、三國信啓、菊池隆幸、横山洋平、松本理器、池田昭夫、浦山慎一、浬本伸克、福山秀直
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-10-02
• [Presentation] Brain representation of human price bidding. (2008)
  • Author(s): Votinov M、美馬達哉、阿部十也、麻生俊彦、澤本伸克、篠崎淳、福山秀直
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] パーキンソン病における皮質基底核ループの障害モデル:機能画像法による検討 (2008)
  • Author(s): 澤本伸克、小栗卓也、椨勇人、浦山慎一、河嶋秀和、石津浩一、高橋良輔、福山秀直
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] ヒトの運動機能に皮質基底核ループが関わる:機能画像法による検討 (2008)
  • Author(s): 小栗卓也、澤本伸克、浦山慎一、福山秀直
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] 初期パーキンソン病患者におけるMIBG心筋シンチの診断的意義の検討 (2008)
  • Author(s): 椨勇人、澤本伸克、河嶋秀和、石津浩一、福山秀直、高橋良輔
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] ヒトの前頭・頭頂葉間の皮質間ネットワーク:機能・画像的解析による脳内回路の同定 (2008)
  • Author(s): 松本理器、澤本伸克、浦山慎一、三國信啓、ティモシー・ベーレンス、池田昭夫、福山秀直、高橋良輔
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] 筋萎縮性側索硬化症における白質変性の評価 (2008)
  • Author(s): 近藤孝之、澤本伸克、井上治久、松本理器、川又純、池田昭夫、福山秀直、高橋良輔
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] A temporal comparison of diffusion-weighted fMRI,NIRS and BOLD responses to visual stimuli in adult humans. (2008)
  • Author(s): Kohno S, Sawamoto N, Urayama S, Aso T, Seiyama A, LeBihan D, Fukuyama H
  • Organizer: The 16th Scientific Meeting of the Intermational Society for Magnetic Resonance in Medicine
  • Place of Presentation: カナダ、トロント
  • Year and Date: 2008-05-06
• [Presentation] Estimation of vascular contribution to DfMRI (Diffusion weighted fMRI) signal. (2008)
  • Author(s): Urayama S, Aso K, Aso T, Kohno S, Sawamoto N, Fukuya H, LeBihan D
  • Organizer: The 16th Scientific Meeting of the Intermational Society for Magnetic Resonance in Medicine
  • Place of Presentation: カナダ、トロント
  • Year and Date: 2008-05-06
• [Presentation] Comparison of Diffusion and Hemodynamic Response Functions in Human Visual Cortex. (2008)
  • Author(s): Aso T, Urayama S, Sawamoto N, Fukuyama H, LeBihan D.
  • Organizer: The 16th Scientific Meeting of the Intermational Society for Magnetic Resonance in Medicine
  • Place of Presentation: カナダ、トロント
  • Year and Date: 2008-05-06
• [Presentation] Increased Change in Water Dffuction MRI following Low frequency Repetitive Transcranial Magnetic Stimulation. (2008)
  • Author(s): Abe M, Mima T, Sawamoto N, Urayama S, Aso T, LeBihan D, Fukuyama H
  • Organizer: The 16th Scientific Meeting of the Intermational Society for Magnetic Resonance in Medicine.
  • Place of Presentation: カナダ、トロント
  • Year and Date: 2008-05-05
• [Book] 神経放射線学的検査:内科学書改訂第7版(小川聡総編集) (2009)
  • Author(s): 澤本伸克、山内浩、福山秀直
  • Total Pages: 229-232
  • Publisher: 中山書店
• [Remarks] ホームページ等
  • URL: http://hbrc.kuhp.kyoto-u.ac.jp/