2010 Fiscal Year Final Research Report
Relationship between side effects of antiparkinsonian agents and dopaminergic regulatory mechanism of adenosine receptors measured with PET
| Project/Area Number |
20591033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
MISHINA Masahiro Nippon Medical School, 医学部, 講師 (70322518)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経機能画像学 / パーキンソン病 / PET / アデノシン受容体 |
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| Research Abstract |
Adenosine A^<2A> receptors (A2ARs) are thought to interact negatively with the dopamine D_2 receptor (D2R). We developed PET ligands for mapping adenosine receptors, and we successfully visualized A2ARs with ^<11>C-TMSX. In this study, we investigated A2ARs in the striata of drug-naive PD patients and PD patients with dyskinesia using ^<11>C-TMSX PET. Our study demonstrated that the A2ARs in the putamen were increased in the PD patients with dyskinesia, and also suggested that the A2ARs in the putamen compensate for the asymmetrical decrease of dopamine in drug-naive PD patients and that antiparkinsonian therapy increases the A2ARs in the putamen. The A2ARs may play an important role in regulation of parkinsonism in PD.
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[Journal Article] Adenosine A2A Receptors Measured with [<11>^C]TMSXPET in the Striata of Parkinson's Disease Patients.2011
Author(s)
Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii k
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Journal Title
PLoS One 6 : e17338
Pages: 1-8
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[Presentation] Comparison of putaminal adenosine A_<2A> receptors in de novo Parkinson's disease with in normals A TMSX PET study.2009
Author(s)
Mishina M, Ishii K, Kitamura S,Naganawa M, Kimura Y, Hashimoto M, Suzuki M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kim K, Kobayashi S, Katayama Y, Ishiwata K
Organizer
The 39th Annual Meeting of the Society For Neuroscience
Place of Presentation
Chicago
Year and Date
20091017-20091021
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[Presentation] Variations in adenosine A_<2A> receptors following anti-parkinsonian therapy indrug nave Parkinson's disease using <11>^C-TMSX PET.2008
Author(s)
Mishina M, Ishii K, Kitamura S,Kimura Y, Naganawa M, Hashimoto M, Suzuki M, Oda K, Hamamoto M, Kobayashi S, Katayama Y, Ishiwata K
Organizer
The Movement Disorder Society's 12th International Congress of Parkinson's Disease and Movement Disorders
Place of Presentation
Chicago
Year and Date
20080622-20080626
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