2010 Fiscal Year Final Research Report
Evaluation of matrix metalloproteinase inhibitors for the therapy for muscular dystrophy
| Project/Area Number |
20591035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Teikyo University of Science & Technology |
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Principal Investigator |
HAGIWARA Hiroki Teikyo University of Science & Technology, 医療科学部, 教授 (80276732)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Fumiaki 帝京大学, 医学部, 助教 (40286993)
MATSUMURA Kiichirou 帝京大学, 医学部, 准教授 (50260922)
SHIMIZU Teruo 帝京大学, 医学部, 教授 (00107666)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マトリックスメタロプロテアーゼ / ジストログリカン / 筋ジストロフィー / モデル動物 / 神経科学 / ヒストン脱アセチル化酵素阻害薬 |
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| Research Abstract |
We studied whether matrix metalloproteinase inhibitors (MMPIs) are effective for the therapy for muscular dystrophy at first. We showed that histone deacetylase inhibitors (HDACIs) promote myotube formation more efficiently than MMPIs. However, its exact mechanism remains unknown. We found that TSA enhances myogenesis by coordinating myogenic regulatory factors and transcriptional repressor.
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