2010 Fiscal Year Final Research Report
Neural transmission abnormality in focal dystonia-focusing on dopaminergic and adenosine systems
| Project/Area Number |
20591038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
ISHII Kenji Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究部長 (10231135)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳神経疾患 / ジストニア / 眼瞼痙攣 / PET / 神経受容体 |
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| Research Abstract |
The purpose of this study was to investigate the pathophysiological mechanism of focal dystonia with Positron Emission Tomography and Magnetic Resonance Imaging for the development of effective treatment. We examined the brains of essential blepharospasm (EBS) patients and found that the dopamine D_2 receptor density was declined, the glucose metabolism in the thalamus was elevated in patients with photophobia, Adenosine A_1 receptor density was unremarkable in the striatum, and the gray matter density in the primary sensory-motor cortex in the face region was increased. These findings suggest the functional abnormality in the brain of focal dystonia patients.
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