2010 Fiscal Year Final Research Report
Investigation for suppressing function of the transcription factor SREBP-1, to develop therapeutic approach to Metabolic Syndrome.
| Project/Area Number |
20591044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TAKAHASHI Akimitsu University of Tsukuba, 大学院・人間総合科学研究科, 講師 (70344893)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMANO Hitoshi 筑波大学, 大学院・人間総合科学研究科, 教授 (20251241)
YATOH Shigeru 筑波大学, 大学院・人間総合科学研究科, 講師 (50451703)
SUZUKI Hiroaki 筑波大学, 大学院・人間総合科学研究科, 准教授 (40344890)
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| Project Period (FY) |
2008 – 2010
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| Keywords | メタボリックシンドローム / 転写因子 |
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| Research Abstract |
The suppression of SREBP-1 resulted markedly improve the hypertriglyceridemia in the mice whose LDL receptor(LDLR) disrupted and which were fed high-fat-high-calorie diet. And in mouse-peritoneal macrophages, both of SREBP-1a and -1c isoforms were expressed and suppression of both isoforms by RNA interference caused less synthesis of fatty-acids or cholesterols. Furthermore, LDLR/SREBP-1 double knockout mice showed decrement in atherosclerotic lesion formation. Those findings suggest that SREBP-1 suppression could be a therapeutic strategy for metabolic syndrome.
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[Journal Article] Sterol Regulatory Element-Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.2011
Author(s)
Karasawa T, Takahashi A, Saito R, Sekiya M, Igarashi M, Iwasaki H, Miyahara S, Koyasu S, Nakagawa Y, Ishii K, Matsuzaka T, Kobayashi K, Yahagi N, Takekoshi K, Sone H, Yatoh S, Suzuki H, Yamada N, Shimano H
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Journal Title
Arterioscler Thromb Vasc Biol. (印刷中)
Peer Reviewed
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