2010 Fiscal Year Final Research Report
Mechanism of Insulin Sensitivity Regulation by the SUMO conjugating enzyme, Ubc9
| Project/Area Number |
20591046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
SHIBATA Hiroshi Gunma University, 生体調節研究所, 准教授 (20235584)
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| Project Period (FY) |
2008 – 2010
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| Keywords | インスリン感受性 / 脂肪細胞 / 糖輸送 / SUMO化 / Ubc9 / GLUT4 / レトロマー複合体 |
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| Research Abstract |
In the present study, we showed that SUMO-conjugating enzyme Ubc9 regulates the insulin sensitivity of glucose transport via GLUT4 subcellular targeting and turnover in adipocytes. In addition, we showed that the retromer complex which is involved in the endosome-to-TGN transport plays an important role in the regulation of GLUT4 turnover.
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