2010 Fiscal Year Final Research Report
The roles of TCF7L2 gene in the development of pancreas and pathogenesis of diabetes
| Project/Area Number |
20591055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
AIDA Kaoru University of Yamanashi, 医学部附属病院, 講師 (50184015)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tetsuro 山梨大学, 医学工学総合研究部, 教授 (30113442)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖尿病 / 膵発生 / 再生医療 / TCF7L2遺伝子 / β-catenin |
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| Research Abstract |
Wng signaling cascade has a crucial role in development of many tissues. The TCF7L2 gene product is a transcription factor involved in the cascase, and is reported to be related to the pathogenesis of type 2 diabetes. We have costruct a pancreas-specific knock-out mouse of β-catenin, an upstream gene of TCF7L2. Unexpectedly, those mice had normal glucose tolerance and normal pancreatic architecture. We are analyzing active TCF7L2-overexpressing mice.
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[Journal Article] RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates b-cell death in fulminant type 1 diabetes.2011
Author(s)
Kaoru Aida, Yoriko Nishida, Shoichiro Tanaka, Taro Maruyama, Akira Shimada, Takuya Awata, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Ichijo, Daiichiro Akiyama, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Jun Itakura, Hideki Fujii, Toyoshi Endo, Tetsuro Kobayashi
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Journal Title
Peer Reviewed
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[Journal Article] Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit -A Mechanism of Accelerated Beta-Cell Failure in Fulminant Type 1 Diabetes-.2009
Author(s)
Shoichiro Tanaka, Yoriko Nishida, Kaoru Aida, Taro maruyama, Akira Shimada, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Takahashi, Daiichiro Akiyama, Sayaka Arai-Yamashita, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Ryohei Katoh, Toyoshi Endo, Tetsuro Kobayashi
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Journal Title
Diabetes 58
Pages: 2285-2291
Peer Reviewed
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