Investigations of S1P receptors as novel therapeutic targets for metabolic syndrome

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Nagoya University
• Principal Investigator: HAMADA Yoji Nagoya University, 医学系研究科, 寄附講座准教授 (20293706)
• Co-Investigator(Kenkyū-buntansha): NAGASAKI HIROSHI 名古屋大学, 大学院・医学系研究科, 寄附講座講師 (30420384)
• Project Period (FY): 2008 – 2010
• Keywords: メタボリック・シンドローム / 脂肪細胞 / S1P受容体 / アディポサイトカイン

Research Abstract

Increased secretion of inflammatory adipocytekines has been related to the pathogenesis of metabolic syndrome. Present study revealed that sphingosine 1-phosphate (S1P) stimulated inflammatory adipocytokine secretion such as IL-6 and MCP-1 from mature adipocytes, mediated by an receptor S1P3 among five subtype receptors for S1P. The specific inhibitor for S1P3 was effective to suppress these inflammatory adipocytokines, which suggest that the S1P3 specific inhibitor may ameliorate the pathophysiology of metabolic syndrome.

Research Products

• [Journal Article] Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways. (2011)
  • Author(s): Suzuki J, Akahane K, Nakamura J, Naruse K, Kamiya H, Himeno T, Nakamura N, Shibata T, Kondo M, Nagasaki H, Fujiya A, Oiso Y, Hamada Y.
  • Journal Title: Neuroscience 176 Pages: 188-198
  • Peer Reviewed
• [Journal Article] Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1. (2009)
  • Author(s): Nakamura N, Naruse K, Matsuki T, Hamada Y, Nakashima E, Kamiya H, Matsubara T, Enomoto A, Takahashi M, Oiso Y, Nakamura J
  • Journal Title: FEBS Lett 583 Pages: 2457-2463
  • Peer Reviewed
• [Journal Article] Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. (2009)
  • Author(s): Tsukahara T, Nakashima E, Watarai A, Hamada Y, Naruse K, Kamiya H, Nakamura N, Kato N, Hamajima N, Sekido Y, Niwa T, Tomita M, Oiso Y, Nakamura J
  • Journal Title: Diabetes Res Clin Pract 84 Pages: 179-186
  • Peer Reviewed
• [Journal Article] Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats (2008)
  • Author(s): Shibata T, Naruse K, Kamiya H, Kozakae M, Kondo M, Yasuda Y, Nakamura N, Ota K, Tosaki T, Matsuki T, Nakashima E, Hamada Y, Oiso Y, Nakamura J
  • Journal Title: Diabetes 57 Pages: 3099-3107
  • Peer Reviewed
• [Journal Article] High glucose-induced upregulation of Rho/Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells. (2008)
  • Author(s): Akiyama N, Naruse K, Kobayashi Y, Nakamura N, Hamada Y, Nakashima E, Matsubara T, Oiso Y, Nakamura J
  • Journal Title: J Mol Cell Cardiol 46 Pages: 326-332
  • Peer Reviewed
• [Journal Article] Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons. (2008)
  • Author(s): Tosaki T, Kamiya H, Yasuda Y, Naruse K, Kato K, Kozakae M, Nakamura N, Shibata T, Hamada Y, Nakashima E, Oiso Y, Nakamura J
  • Journal Title: Exp Neurol 213 Pages: 381-387
  • Peer Reviewed
• [Journal Article] Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5). (2008)
  • Author(s): Okajima Y, Nagasaki H, Suzuki C, Suga H, Ozaki N, Arima H, Hamada Y, Civelli O, Oiso Y
  • Journal Title: Regul Pept 148 Pages: 62-67
  • Peer Reviewed
• [Journal Article] Low serum culture system improves adipogenic ability of visceral adipose tissue derived stromal cell.
  • Author(s): Nagasaki H, Suzuki T, Hashimoto H, Shang QL, Yoshimura T, Kondo T, Ozaki T, Maruyama S, Johmori T, Oiso Y, Hamada Y.
  • Journal Title: Cell Biology International In press
  • Peer Reviewed
• [Presentation] 胆汁酸代謝とインスリン抵抗性に対するα-グルコシダーゼ阻害薬ミグリトールの作用 (2010)
  • Author(s): 濱田洋司、長崎弘、渕上昌弘、大磯ユタカ
  • Organizer: 第31回日本肥満学会年次学術集会
  • Place of Presentation: 前橋市
  • Year and Date: 2010-10-22
• [Presentation] メタボリックシンドロームにおける血清遊離脂肪酸およびセラミド濃度の検討-病態および脂質摂取との関連について (2010)
  • Author(s): 濱田洋司、河村孝彦、長崎弘、鈴木淳也、大磯ユタカ
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2010-05-28
• [Presentation] パルミチン酸によるSchwann細胞のアポトーシス誘導機序の検討 (2009)
  • Author(s): 鈴木淳也、太田貴美子、神谷英紀、中村二郎、長崎弘、大磯ユタカ、濱田洋司
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Presentation] 3T3-L1脂肪細胞からのInterleukin-6分泌に対するセラミド代謝の影響 (2008)
  • Author(s): 濱田洋司、長崎弘、鈴木淳也、大磯ユタカ
  • Organizer: 第51回日本糖尿病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-24
• [Book] 新時代の糖尿病学(4)(分担執筆) (2008)
  • Author(s): 濱田洋司
  • Total Pages: 712
  • Publisher: 日本臨床