2010 Fiscal Year Final Research Report
Identification and characterization of a new factor regulating SREBP-1c gene in liver.
Project/Area Number |
20591058
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
NISHIO Yoshihiko Shiga University of Medical Science, 医学部, 准教授 (40281084)
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Project Period (FY) |
2008 – 2010
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Keywords | 脂質合成 / 転写調節 / 栄養素 |
Research Abstract |
We have shown that RBMX and its binding protein SAFB regulate the transcriptional activity of SREBP-1c gene. Furthermore, we have identified a new gene, hepothetical protein LOC 673353, really expressing as mRNA and protein regulating SREBP-1c gene.
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[Journal Article] Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues.2010
Author(s)
Ugi S, Nishio Y, Yamamoto H, Ikeda K, Kobayashi M, Tsukada S, Kondo M, Morino K, Obata T, Yoshizaki T, Uzu T, Naitoh H, Tani T, Maeda S, Kashiwagi A, Maegawa H.
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Journal Title
Obesity (Silver Spring). 18(7)
Pages: 1277-1282.
Peer Reviewed
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[Journal Article] Transcription factor AP-2beta : a negative regulator of IRS-1 gene expression.2010
Author(s)
Meng X, Kondo M, Morino K, Fuke T, Obata T, Yoshizaki T, Ugi S, Nishio Y, Maeda S, Araki E, Kashiwagi A, Maegawa H.
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Journal Title
Biochem Biophys Res Commun. 19;392(4)
Pages: 526-532.
Peer Reviewed
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[Journal Article] SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.2009
Author(s)
Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Morino K, Maeno Y, Obata T, Ugi S, Maegawa H, Kimura H, Kashiwagi A.
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Journal Title
BMB Rep. 30;42(4)
Pages: 232-237.
Peer Reviewed
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[Journal Article] Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia.2009
Author(s)
Ugi S, Shi K, Nishio Y, Shimizu S, Guo B, Sekine O, Ikeda K, Egawa K, Yoshizaki T, Nagai Y, Koya D, Takada T, Torii R, Kimura H, Kashiwagi A, MaegawaH.
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Journal Title
J Biochem. 146(4)
Pages: 541-547.
Peer Reviewed
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[Presentation] RNA binding motif protein on the X chromosome (RBMX), a novel key molecule for developing metabolic syndrome and NASH.2009
Author(s)
Maeno Y, Nishio Y, Nagai Y, Takemoto T, Sekine O, Omura Y, Ushio M, Kimura H, Kashiwagi A, Maegawa H
Organizer
14th International Congress of Endocrinology
Place of Presentation
Kyoto
Year and Date
20090000
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[Presentation] A Newly Identified Protein, LOC673353, Activates the Promoter of SREBP-1c Gene through Direct Binding to Its Promoter and Association with a Co-Activator, RBMX.2008
Author(s)
Sekine O, Nishio Y, Ikeuchi C, Takemoto T, Quynh N, Ugi S, Maegawa H, Kimura H, Kashiwagi A
Organizer
68th annual meeting of American Diabetes Association
Place of Presentation
San Francisco
Year and Date
20080000
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[Presentation] Safb1, an RBMX-Binding Protein, is a Newly Identified Activator in the Regulation of Hepatic SREBP-1 Gene Expression.2008
Author(s)
Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Morino K, Maeno Y, Obata T, Ugi S, Maegawa H, Kimura H, Kashiwagi A
Organizer
68th annual meeting of American Diabetes Association
Place of Presentation
San Francisco
Year and Date
20080000
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