2010 Fiscal Year Final Research Report
SNPs drived form diabetes GWAS and incidence of diabetes in a general population : the Hisayama Study
| Project/Area Number |
20591063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyushu University |
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Principal Investigator |
DOI Yasufumi Kyushu University, 病院, 助教 (00419566)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Michiaki 独立行政法人理化学研究所, 横浜研究所ゲノム医科学研究センター, 副センター長 (30442958)
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOHARA Yutaka 九州大学, 医学研究院, 教授 (80161602)
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| Project Period (FY) |
2008 – 2010
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| Keywords | エネルギー / 糖質代謝異常 |
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| Research Abstract |
Objective : Few prospective studies have examined the association between SNPs derived form GWAS of diabetes and the incidence of diabetes in general populations. Methods : A total of 2,231 community-dwelling Japanese individuals aged 40 and more without diabetes were followed up for 7 years. During the follow-up, 228 subjects was diagnosed newly diabetes. Results : The age- and sex-adjusted hazard ratios (HRs) for the development of diabetes was significantly higher in subjects with the SNPs on the CDKAL1, CDKN2A/2B, DCD, FTO, KCNQ1 and HNF4A genes. When divided into four groups, namely 0-4, 5, 6, 7 and more, according to the number of risk polymorphisms in the six genes, the multivariable adjusted-HRs for the development of diabetes significantly increased if subjects had five and more risk polymorphisms compared to individuals who had 0-4 risk polymorphisms (6 risk polymorphisms : adjusted HR=1.8:6 risk polymorphisms : adjusted HR=2.0:7 and more risk polymorphisms : adjusted HR=3.1). The area under the receiver operating characteristic curve significantly increased by adding the number of risk polymorphisms to the model including other potential risk factors (0.732)compared with those of other potential risk factors only (0.706) (p for difference in the area=0.008). In conclusion, the number of risk polymorphisms was a significant risk factor for the development of diabetes.
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[Journal Article] Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community : the Hisayama Study.2010
Author(s)
Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, Arima H, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y
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Journal Title
Acta Psychiatr Scand 122
Pages: 319-325
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[Journal Article] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.2010
Author(s)
Matsushita T, Umeno J, Hirakawa Y, Yonemoto K, Ashikawa K, Amitani H, Ninomiya T, Hata J, Doi Y, Kitazono T, Iida M, Nakamura Y, Kiyohara Y, Kubo M
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Journal Title
J Hum Genet 55
Pages: 473-476
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[Journal Article] Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke.2010
Author(s)
Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M
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Journal Title
Hum Mol Genet 19
Pages: 1137-1146
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[Journal Article] QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population : the Hisayama study.2010
Author(s)
Maebuchi D, Arima H, Doi Y, Ninomiya T, Yonemoto K, Tanizaki Y, Kubo M, Hata J, Matsumura K, Iida M, Kiyohara Y
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Journal Title
Hypertens Res 33
Pages: 916-921
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[Journal Article] Lack of association between variations of PDE4D and ischemic stroke in the Japanese population.2009
Author(s)
Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y
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Journal Title
Stroke 40
Pages: 1245-1251
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[Journal Article] Incidence and survival of dementia in a general population of Japanese elderly : the Hisayama study.2009
Author(s)
Matsui Y, Tanizaki Y, Arima H, Yonemoto K, Doi Y, Ninomiya T, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y
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Journal Title
J Neurol Neurosurg Psychiatry 80
Pages: 366-370
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[Journal Article] Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection : a population-based cohort study.2009
Author(s)
Ikeda F, Doi Y, Yonemoto K, Ninomiya T, Kubo M, Shikata K, Hata J, Tanizaki Y, Matsumoto T, Iida M, Kiyohara Y
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Journal Title
Gastroenterology 136
Pages: 1234-1241
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