2010 Fiscal Year Final Research Report
Development of predictive marker for the progression of type 1 diabetes using a newly discovered autoantigen
| Project/Area Number |
20591064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Nagasaki University |
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Principal Investigator |
KAWASAKI Eiji Nagasaki University, 病院, 准教授 (70336171)
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| Co-Investigator(Kenkyū-buntansha) |
ABIRU Norio 長崎大学, 医歯薬学総合研究科, 講師 (00380981)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 1型糖尿病 / 自己抗体 / 自己抗原 / 亜鉛 / 一塩基多型 / 劇症1型糖尿病 |
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| Research Abstract |
In the prospective study of GAD autoantibody-positive NIDDM, the high levels of GAD autoantibody, the GAD65 middle epitope recognition, and positivity of other anti-islet autoantibodies (insulin autoantibody, IA-2 autoantibody, and ZnT8 autoantibody) were identified as predictive markers for the progression of insulin deficiency. Furthermore, multivariate logistic regression analysis of the likelihood of requiring insulin showed that only the presence of multiple islet autoantibodies was a significant predictor. Moreover, the difference of humoral autoimmune reaction to ZnT8 was proven by age of diabetes onset by the ZnT8 autoantibody epitope analysis.
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[Journal Article] Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients.2011
Author(s)
Kawasaki E, Nakamura K, Kuriya G, Satoh T, Kobayashi M, Kuwahara H, Abiru N, Yamasaki H, Matsuura N, Miura J, Uchigata Y, Eguchi K.
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Journal Title
Clin Immunol 138
Pages: 146-153
Peer Reviewed
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[Journal Article] Trajectories of anti-islet autoantibodies before development of type 1 diabetes in interferon-treated hepatitis C patients. Case reports and a literature review.2010
Author(s)
Nakamura K, Kawasaki E, Abiru N, Jo O, Fukushima K, Satoh T, Kuriya G, Kobayashi M, Kuwahara H, Yamasaki H, Ide T, Eguchi K.
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Journal Title
Endocr J 57
Pages: 947-951
Peer Reviewed
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[Journal Article] Autoantibodies to insulin, insulinoma-associated antigen-2,and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes.2010
Author(s)
Kawasaki E, Nakamura K, Kuriya G, Satoh T, Kuwahara H, Kobayashi M, Abiru N, Yamasaki H, Eguchi K.
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Journal Title
J Clin Endocrinol Metab 95
Pages: 707-713
Peer Reviewed
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[Journal Article] Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.2009
Author(s)
Kawasaki E, Uga M, Nakamura K, Kuriya G, Satoh T, Fujishima K, Ozaki M, Abiru N, Yamasaki H, Wenzlau JM, Davidson HW, Hutton JC, Eguchi K.
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Journal Title
Diabetologia 51
Pages: 2299-2302
Peer Reviewed
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