2010 Fiscal Year Final Research Report
Impact of mitochondrial reactive oxygen species in the pathogenesis of diabetic nephropathy
| Project/Area Number |
20591065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
NISHIKAWA Takeshi Kumamoto University, 大学院・生命科学研究部, 特任准教授 (70336212)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMURA Nobuhiro 熊本大学, 大学院・生命科学研究部, 准教授 (40274716)
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| Project Period (FY) |
2008 – 2010
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| Keywords | エネルギー / 糖代謝異常 |
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| Research Abstract |
We previously reported that mitochondrial reactive oxygen species (mtROS) is one of the major factors in the pathogenesis of diabetic vascular complications. In this study, we examined the impact of mtROS in the pathogenesis of diabetic nephropathy using endothelial cells and transgenic mice, which specifically express manganese superoxide dismutase (MnSOD) in vascular endothelial cells.
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Author(s)
Matsumura T, Kinoshita H, Ishii N, Fukuda K, Motoshima H, Senokuchi T, Taketa K, Kawasaki S, Nishimaki-Mogami T, Kawada T, Nishikawa T, Araki E
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Journal Title
Arterioscler Thromb Vasc Biol in press
Peer Reviewed
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[Journal Article] Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.2011
Author(s)
Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun 404
Pages: 339-344
Peer Reviewed
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[Journal Article] The effect of group-based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome : The Tabaruzaka Study 1.2010
Author(s)
Yamashiro T, Nishikawa T, Isami S, Wei C, Fukumoto K, Matsuo H, Yoshinaga T, Kukidom D, Motoshima H, Matsumura T, Ueda A, Araki E
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Journal Title
Diabetes Obes.Metab. 12
Pages: 790-797
Peer Reviewed
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[Journal Article] Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.2010
Author(s)
Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E
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Journal Title
Arterioscler Thromb Vasc Biol 30
Pages: 1598-1605
Peer Reviewed
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[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.2009
Author(s)
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
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Journal Title
Biochem Biophys Res Coromun 379
Pages: 806-811
Peer Reviewed
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[Journal Article] Activation of AMP-activated protein kinase suppresses oxidised low-density lipoprotein-induced macrophage proliferation.2009
Author(s)
Ishii N, Matsumura T, Kinoshita H, Motoshima H, Kojima K, Tsutsumi A, Kawasaki S, Yano M, Senokuchi T, Asano T, Nishikawa T, Araki E
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Journal Title
J Biol Cbem 284
Pages: 34561-34569
Peer Reviewed
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[Journal Article] Rottlerin activates AMPK possibly through LKBl in vascular cells and tissues.2008
Author(s)
Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E
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Journal Title
Biochem Biophys Res Commun 376
Pages: 434-438
Peer Reviewed
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[Presentation] ミトコンドリア異常と血管合併症2009
Author(s)
西川武志, 久木留大介, 園田和洋, 切通伸介, 藤澤和洋, 山城武司, 後藤秀生, 荒木栄一
Organizer
第52回日本糖尿病学会総会
Place of Presentation
大阪国際会議場
Year and Date
20090521-20090524
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