2010 Fiscal Year Final Research Report
RAGE and soluble RAGE mediated regulation of obesity and atherosclerosis
| Project/Area Number |
20591067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
KOYAMA Hidenori Osaka City University, 医学部, 准教授 (80301852)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Shinya 大阪市立大学, 大学院・医学研究科, 講師 (90381996)
TANAKA Shinji 大阪市立大学, 大学院・医学研究科, 講師 (20448749)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Hiroshi 金沢大学, 大学院・医学系研究科, 教授 (00115198)
ELAINE W.Raines University of Washington, Department of Pathology, Professor
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| Project Period (FY) |
2008 – 2010
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| Keywords | 終末糖化産物 / 肥満 / メタボリックシンドローム / インスリン抵抗性 / 動脈硬化 |
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| Research Abstract |
Advanced glycation end-products, AGEs and their receptor, RAGE, has been implicated in vascular complications in diabetes. In this study, we show that RAGE is involved in adiposity and atherosclerosis induced by high fat diet in non-diabetic condition, where RAGE regulated plasma adiponectin take an important role. Moreover, gene chip analyses of mRNA specifically regulated by RAGE-deficient adipose tissues reveal that insulin signaling and adipocyte differentiation pathway are potential targets of RAGE, which could contribute to adiposity and altered adipocytokine regulation.
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[Journal Article] Advanced glycation end-products, carotid atherosclerosis and circulating endothelial progenitor cells in patients with end-stage renal disease.2011
Author(s)
Ueno H, Koyama H, Fukumoto S, Tanaka S, Shoji T, Shoji T, Emoto M, Tahara H, Inaba M, Kakiya R, Tabata T, Miyata M, Nishizawa Y
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Journal Title
Metabolism 60
Pages: 453-9
Peer Reviewed
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[Journal Article] Dialysis modality is independently associated with circulating endothelial progenitor cells in end-stage renal diseases patients.2010
Author(s)
Ueno H, Koyama H, Fukumoto S, Tanaka S, Shoji T, Shoji T, Emoto M, Tahara H, Tsujimoto Y, Tabata T, Nishizawa Y
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Journal Title
Nephrol Dial Transplant 25
Pages: 581-6
Peer Reviewed
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[Journal Article] Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apo E-deficient mouse.2010
Author(s)
Ueno H, Koyama H, Shoji T, Kurato M, Fukumoto S, Tanaka S, Otsuka Y, Mima Y, Morioka T, Mori M, Shioi A, Yamamoto H, Inaba M, Nishizawa Y
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Journal Title
Atherosclerosis 211
Pages: 431-6
Peer Reviewed
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[Journal Article] Skin autofluorescence, a marker for advanced glycation end product accumulation, is associated with arterial stiffness in patients with end-stage renal disease.2008
Author(s)
Ueno H, Koyama H, Tanaka S, Fukumoto S, Shinohara K, Shoji T, Emoto M, Tahara H, Kakiya R, Tabata T, Miyata T, Nishizawa Y
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Journal Title
Metabolism 57
Pages: 1452-7
Peer Reviewed
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[Presentation] Receptor for advanced glycation end-products (RAGE) is involved in progression of adipogenesis and atherosclerosis in non-diabetic status.2008
Author(s)
Shoji T, Ueno H, Koyama H, Fukumoto S, Tanaka S, Murayama M, Otsuka Y, Mima Y, Mori K, Shioi A, Yamamoto H, Nishizawa Y
Organizer
The 68th Scientific Sessions of American Diabetes Association
Place of Presentation
San Francisco, CA
Year and Date
20080606-20080613
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