2010 Fiscal Year Final Research Report
Effective strategy to treat type 2 diabetes by blockade of ghrelin signaling in islet β-cells
| Project/Area Number |
20591070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
DEZAKI Katsuya Jichi Medical University, 医学部, 准教授 (90337329)
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| Co-Investigator(Kenkyū-buntansha) |
YADA Toshihiko 自治医科大学, 医学部, 教授 (60166527)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生理学 / 糖尿病 / インスリン分泌 / シグナル伝達 |
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| Research Abstract |
Ghrelin, an acylated 28-amino acid peptide, was isolated from the stomach as the endogenous ligand for growth hormone-secretagogue receptor (GHS-R). In addition to its unique role in regulating mealtime hunger and lipid metabolism, we have reported the physiological role of ghrelin in the regulation of insulin release and glucose metabolism. In this study, we uncovered that the signal transduction mechanisms of ghrelin in islet β-cells are very unique, being distinct from those utilized for growth hormone release. In type 2 diabetec GK rats, blockade of β-cell ghrelin receptor enhanced insulin release and prevents impaired glucose tolerance. Thus, manipulation of insulinostatic function of ghrelin?GHS-R system in islets could optimize the amount of insulin release to meet the systemic demand, providing a potential therapeutic application to prevent type 2 diabetes.
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[Journal Article] Reconstruction- dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats.2010
Author(s)
Koizumi M, Dezaki K, Hosoda H, Damdindorj B, Sone H, Ming L, Hosoya Y, Sata N, Kobayashi E, Kangawa K, Nagai H, Yasuda Y, Yada T.
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Journal Title
Int J Pept
Pages: pii365416
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[Journal Article] Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.2010
Author(s)
Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, Takano E, Gantulga D, Iwasaki Y, Kurashina T, Onaka T, Dezaki K, Nakata M, Mori M, Yada T.
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Journal Title
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[Journal Article] Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin- independent melanocortin pathway.2009
Author(s)
Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh-I S, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T.
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Journal Title
Cell Metab 10
Pages: 355-365
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[Journal Article] Regulation of voltage-gated K^+ channels by glucose metabolism in pancreatic υ-cells.2009
Author(s)
Yoshida M, Dezaki K, Yamato S, Aoki A, Sugawara H, Toyoshima H, Ishikawa SE, Kawakami M, Nakata M, Yada T, Kakei M.
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Journal Title
FEBS Lett 583
Pages: 2225-2230
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