2010 Fiscal Year Final Research Report
Effect of lipoprotein mediated by sphingosine-1 phosphate receptors and scavenger receptor class B type I
| Project/Area Number |
20591077
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
KIMURA Takao Gunma University, 医学部, 助教 (90396656)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 動脈硬化 / 血管内皮 / HDL / SR-BI / スフィンゴシン1-リン酸 |
|---|
| Research Abstract |
HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of the cholesterol metabolism. Here, we showed the cross-talk mechanism between statins and HDL in anti-inflammatory and anti-atherogenic actions, with a focus on scavenger receptor class B type I. Simvastatin treatment of HUVECs induces expression of SR-BI, which plays a critical role as a key molecule to enhance HDL-induced anti-inflammatory actions, including NOS activation and inhibition of adhesion molecule expression.
|
Research Products
(17 results)
-
[Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010
Author(s)
Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
-
Journal Title
J Biol Chem. 285(7)
Pages: 4387-4397
Peer Reviewed
-
-
-
-
-
[Journal Article] Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.2009
Author(s)
Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F
-
Journal Title
J Immunol. 182(5)
Pages: 3243-3251
Peer Reviewed
-
[Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.2009
Author(s)
Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, Okajima F
-
Journal Title
Carcinogenesis. 30(3)
Pages: 457-465
Peer Reviewed
-
-
[Presentation] Rapid non-genomic action of thyroid hormone and the expression of deiodinase in endothelial cells.2010
Author(s)
T.Kimura, T.Aoki, K.Sato, A.Kuwabara, M.Nara, K.Tsunekawa, T.Morimura, O.Araki, H.Sumino, H.Tomura, I.Kobayashi, Y.Kondo, F.Okajima, M.Murakami
Organizer
第14回国際甲状腺学会
Place of Presentation
パリ国際会議場(パリ、フランス共和国)
Year and Date
2010-09-12
-
-
-
-
-
-
-
-
