2010 Fiscal Year Final Research Report
Functional analysis of CCN3, a novel growth inhibitor for vascular smooth muscle cells, and its application in the treatment of vascular diseases.
| Project/Area Number |
20591078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Chiba University |
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Principal Investigator |
YOKOTE Koutaro Chiba University, 大学院・医学研究院, 教授 (20312944)
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| Project Period (FY) |
2008 – 2010
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| Keywords | CCN / 動脈硬化 / 平滑筋細胞 / 増殖 / 遊走 / 糖尿病 |
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| Research Abstract |
CCN3 belongs to CCN family, which constitutes multifunctional secreted proteins that act as matricellular regulators. CCN3 suppressed the rat smooth muscle cells (VSMC) migration as well as proliferation induced by fetal bovine serum. CCN3 knockout mice were created and the neointimal hyperplasia induced by photochemically-induced thrombosis, were investigated. Histopathological evaluation of the arteries 21 days after the endothelial injury revealed a 6-fold enhancement of neointimal thickening in the null mice compared with the wild-type. Our findings indicate the involvement of CCN3 in vascular homeostasis, especially upon injury, and the potential usefulness of this molecule in the modulation of atherosclerotic vascular disease.
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[Journal Article] Primary lung cancer associated with Werner syndrome.2010
Author(s)
Ohnishi, S., Fujimoto, M., Oide, T., Nakatani, Y., Tsurutani, Y., Koshizaka, M., Mezawa, M., Ishikawa, T., Takemoto, M., Yokote, K.
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Journal Title
Geriatr Gerontol Int. 10(4)
Pages: 319-323
Peer Reviewed
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[Journal Article] Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.2010
Author(s)
Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C.
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Journal Title
Proc Natl Acad Sci USA 107
Pages: 7461-7466
Peer Reviewed
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[Journal Article] Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain.2010
Author(s)
Isose S, Misawa S, Sakurai K, Kanai K, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Fujimaki Y, Yokote K, Kuwabara S.
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Journal Title
Clin Neurophysiol. 121
Pages: 719-724
Peer Reviewed
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[Journal Article] Hypoglycemia due to ectopic secretion of insulin-like growth factor-I in a patient with an isolated sarcoidosis of the spleen.2010
Author(s)
Ogiwara Y, Mori S, Iwama M, Sawabe M, Takemoto M, Kanazawa N, Furuta K, Fukuda I, Kondo Y, Kimbara Y, Tamura Y, Chiba Y, Araki A, Yokote K, Maruyama N, Ito H.
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Journal Title
Endocr J. 57
Pages: 325-330
Peer Reviewed
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[Journal Article] CCN3 Inhibits Neointimal Hyperplasia Through Modulation of Smooth Muscle Cell Growth and Migration.2010
Author(s)
Shimoyama,T., Hiraoka, S., Takemoto, M., Koshizaka, M., Tokuyama, H., Tokuyama, T., Watanabe, A., Fujimoto, M., Kawamura, H., Sato, S., Tsurutani, Y., Saito, Y., Perbal, B., Koseki, H., Yokote, K.
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Journal Title
Arterioscler Thromb Vasc Biol.30
Pages: 675-682
Peer Reviewed
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