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2010 Fiscal Year Final Research Report

Analyses on the mechanisms for cholesterol excretion from liver.

Research Project

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Project/Area Number 20591079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

TSUKAMOTO Kazuhisa  The University of Tokyo, 医学部附属病院, 講師 (20251233)

Co-Investigator(Kenkyū-buntansha) ISOーO Naoyuki  東京大学, 医科学研究所, 助教 (80420214)
MORIYA Kyouji  東京大学, 医学部附属病院, 教授 (00272550)
FUJIE Hajime  東京大学, 医学部附属病院, 助教 (90332577)
Project Period (FY) 2008 – 2010
KeywordsABCG5 / ABCG8 / NPC1L1 / 肝臓 / 胆汁
Research Abstract

The liver is the only organ which excretes cholesterol from the body. The present study suggested 1) the existence of liver-specific sterolin which is important for excretion of cholesterol into the bile, and 2) that the cholesterol in the bile was re-absorbed with NPC1L1, which resulted in the production of apoE rich lipoproteins. Furthermore, it has been indicated that cholesterol in the liver, depending on its source, exerted distinct metabolic properties.

  • Research Products

    (6 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Plant Sterols Increased IL-6 and TNF-α Secretion from Macrophages, but to a Lesser Extent than Cholesterol.2011

    • Author(s)
      Kurano M, Iso-O N, Hara M, Noiri E, Koike K, Kadowaki T, Tsukamoto K.
    • Journal Title

      J Atheroscler Thromb (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Identification of a novel mutation for phytosterolemia. Genetic analyses of 2 cases.2009

    • Author(s)
      Togo M, Hashimoto Y, Iso-O N, Kurano M, Hara M, Kadowaki T, Koike K, Tsukamoto K.
    • Journal Title

      Clin Chim Acta. 401(1-2)(Epub 2008 Nov 5)

      Pages: 165-9

    • Peer Reviewed
  • [Presentation] Modulation of Lipoprotein and Glucose Metabolism with the Over-expression of Niemann-pick C1 Like 1 Protein (NPC1L1) In Mice Liver.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al.
    • Organizer
      American Heart Association 2010 Scientific Sessions.
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2010-11-16
  • [Presentation] LXR Agonist Increases ApoE Secretion from HepG2 Spheroid Together with Increased Production of VLDL and ApoE-Rich Large HDL.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al.
    • Organizer
      Arterioscler Thromb Vasc Biol 2010 Scientific Sessions.
    • Place of Presentation
      San Francisco, CA, USA.
    • Year and Date
      2010-04-10
  • [Presentation] Plant Sterols Increased Il-6 and TNF-α Secretion from Macrophages but to a Lesser Extent than Cholesterol.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al.
    • Organizer
      Arterioscler Thromb Vasc Biol 2010 Scientific Sessions.
    • Place of Presentation
      San Francisco, CA, USA.
    • Year and Date
      2010-04-09
  • [Presentation] HepG2 スフェロイドのin vitro脂質代謝研究における有用性2010

    • Author(s)
      蔵野信、塚本和久, et al.
    • Organizer
      第44回日本成人病(生活習慣病)学会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-09

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Published: 2012-01-26   Modified: 2014-11-07  

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